PeproTech重组人FGFR3a (IIIc) Fc 1

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价格询价

品牌PeproTech
货号160-05
产地美国
更新日期2025年07月14日

Gibco PeproTech细胞因子（英潍捷基（上海）贸易有限公司）

品牌商

16 年钻石会员

Recombinant Human FGFR3a (IIIc) Fc

Catalog Number:

160-05

Synonyms:

Fibroblast Growth Factor Receptor 3 alpha, ACH, CD333, CEK2, JTK4

Description:

The FGF family plays a central role during prenatal development and postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. The FGF ligands bind to a family of type I transmembrane tyrosine kinase receptors, which leads to dimerization and activation by sequential autophosphorylation of specific tyrosine residues. Four genes encoding structurally related FGF receptors (FGFR-1 to -4) are known. Alternative splicing of the mRNAs generates numerous forms of FGFR-1 to -3. Alternate forms of FGF receptors can exhibit different specificities with respect to ligand binding. For example, the form designated as FGFR1a (IIc) interacts predominantly with FGF-acidic (FGF1) and FGF-basic (FGF2). A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). PeproTech’s CHO cell-derived Recombinant Human FGFR3a (IIIc) Fc is a glycosylated, disulfide-linked homodimer of 1,170 amino acid residues whose monomer consists of the 353-amino-acid length extracellular portion of FGFR3a (IIc) fused to the 231-amino-acid length Fc portion of human IgG1 by a single glycine. The calculated molecular weight of CHO cell-derived Recombinant Human FGFR3a (IIIc) Fc is 128.3 kDa, however, it migrates at an apparent molecular weight of approximately 100-110 kDa by SDS-PAGE analysis under reducing conditions due to glycosylation.

AA Sequence:

(Monomer)E SLGTEQRVVG RAAEVPGPEP GQQEQLVFGS GDAVELSCPP PGGGPMGPTV WVKDGTGLVP SERVLVGPQR LQVLNASHED SGAYSCRQRL TQRVLCHFSV RVTDAPSSGD DEDGEDEAED TGVDTGAPYW TRPERMDKKL LAVPAANTVR FRCPAAGNPT PSISWLKNGR EFRGEHRIGG IKLRHQQWSL VMESVVPSDR GNYTCVVENK FGSIRQTYTL DVLERSPHRP ILQAGLPANQ TAVLGSDVEF HCKVYSDAQP HIQWLKHVEV NGSKVGPDGT PYVTVLKTAG ANTTDKELEV LSLHNVTFED AGEYTCLAGN SIGFSHHSAW LVVLPAEEEL VEADEAGSVY AGGPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGK

Source:

CHO cells

Purity:

Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors. The expected ED₅₀ is ≤ 0.1 μg/ml corresponding to a specific activity of ≥ 2 x 10⁴units/mg.

Research Interests: