TGF-β1, human

Product description:
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is
abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA).
TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature
TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that
TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
Recombinant Human TGFβ-1 is produced by our mammalian cells expression system in HEK293 cells. The
target protein is expressed with sequence (Leu30-Ser390) of Human TGFB1 fused with a polyhistidine tag at the C-terminus.
Purity:
> 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Endotoxin:
<1 EU/μg, determined by LAL method.
Source:
HEK293 cells
Molecular Weight:
12 kDa, observed by reducing SDS-PAGE.
Formulation：
Lyophilized from a 0.2 μM filtered solution of 50 mM Glycin, 50 mM NaCl, pH 4.0.
Reconstitution:
Reconstituted in 1×PBS at 100 μg/ml.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage:
Lyophilized protein should be stored at ≤ -20 ℃, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 ℃ for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20 ℃ for 3 months.
FOR RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR DIAGNOSTIC USE