产品描述:
Interleukin-17A (IL-17A or CTLA-8) induces stromal cells to produce proinflammatory cytokines. IL-17A enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. Human, mouse and rat IL-17A show activity on mouse cells. Recombinant Human IL-17A produced in E. coli is a homodimeric non-glycosylated disulfide-linked homodimer containing two 137 amino acid chains with a MW of 31,332 Da. The recombinant protein corresponds to full-length IL-17A and has cytokine production activity on mouse cells.
形 态 :
Each vial contains 25 ug of lyophilized protein. Reconstitute with 0.25 ml sterile deionized water for a final concentration of 0.1 mg/ml.
来 源 :
E. coli. Endotoxin level as measured by LAL is <0.1 ng/ug or <1 EU/ug.
别 名 :
interleukin-17A; IL-17A; IL-17; Cytotoxic T-lymphocyte-associated antigen 8; IL17A; CTLA8; IL17
纯 度 :
Purity > 98% as determined by reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
分子量 :
31332 Da
应 用 :E, WB
Human IL-17A is fully biologically active when compared to standard. The ED50 as determined by the dose-dependent production of IL-6 in cultured mouse NIH-3T3 fibroblast cells is typically 1.5-7 ng/ml.
保存条件 :
Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
产品链接 :http://www.abbiotec.com/proteins/human-il-17a