GluA 2

Glutamate Receptors and Synaptic Physiology in Developing Neural Circuits

The major excitatory neurotransmitter in the CNS is glutamate. It binds to and activates fast, ligand-gated receptors such as AMPA and NMDA ionotropic receptors. AMPA receptors are composed of 4 subunits (GluA1–4) with varying stoichiometries

Electrophysiological and Biochemical Studies of AMPA Receptor Phosphorylation and Synaptic Plasticity in Hippocampal CA1 Mini-Slices

to behavior. Here we describe our approaches using electrophysiological and biochemical methods with acute mouse hippocampal CA1 mini-slices to study GluA1 phosphorylation during LTP and LTD.

应用案例 | 抑郁症患者的福音，Cell 杂志发文揭示心理韧性的环路机制

初级听觉皮层中接受来自同侧内侧膝状体兴奋性神经元投射的 PV 神经元在慢性社交失败模型中的激活是心理韧性产生的充分必要条件。   CSDS 模型的早期阶段中，应激事件诱发投射到 A1 的 MG 神经元的短期超极化；在随后的应激反应中，通过突触后 glua2 型 AMPA 受体的稳态调节机制，加强 MGPV 神经元和 MGPV 神经元之间的突触传递，同时脑源性神经营养因子（brain-derived neurotrophic factor, BDNF）「供体」神经元被激活并释放 BDNF，BDNF 作用