Recombinant Human NAD(P)H Dehydrogenase Quinone 2
Synonyms DHQV, DIA6, QR2, EC 1.10.99.2, NMOR2, NQO2, NRH:quinone oxidoreductase 2, NRH dehydrogenase [quinone] 2, Ribosyldihydronicotinamide dehydrogenase [quinone].
Introduction NQO2 is a flavoprotein that catalyzes the 2-electron reduction of diverse quinones, redox dyes, and the vitamin K menadione. NQO2 mainly uses dihydronicotinamide riboside (NRH) as the electron donor. NQO2 catalyzes the metabolic detoxification of quinones and their derivatives to hydroquinones. This detoxification process protects cells against quinone-induced oxidative stress, cytotoxicity and mutagenicity.
Recombinant Human NAD(P)H Dehydrogenase Quinone 2Description NQO2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 251amino acids (1-231 a.a.) and having a molecular mass of 28.1 kDa. NQO2 protein is fused to a 20 amino acid His-Tag at N-terminus and purified by standard chromatography.
Source Escherichia Coli.
Physical Appearance Sterile filtered colorless solution.
Formulation NQO2 Human solution (1mg/ml) containing 20mM Tris-HCl pH-8, 1mM DTT & 10% glycerol.
Recombinant Human NAD(P)H Dehydrogenase Quinone 2Stability NQO2 Human although stable at 4℃ for 1 week, should be stored desiccated below -18℃. Please prevent freeze thaw cycles.
Amino acid sequence MGSSHHHHHH SSGLVPRGSH MAGKKVLIVY AHQEPKSFNG SLKNVAVDEL SRQGCTVTVS DLYAMNFEPR ATDKDITGTL SNPEVFNYGV ETHEAYKQRS LASDITDEQK KVREADLVIF QFPLYWFSVP AILKGWMDRV LCQGFAFDIP GFYDSGLLQG KLALLSVTTG GTAEMYTKTG VNGDSRYFLW PLQHGTLHFC GFKVLAPQIS FAPEIASEEE RKGMVAAWSQ RLQTIWKEEP IPCTAHWHFG Q.
Recombinant Human NAD(P)H Dehydrogenase Quinone 2Purity Greater than 95% as determined by SDS-PAGE.
Usage CHI's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.