Ginsenoside Rf

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Ginsenoside Rf

CAS No. : 52286-58-5

MCE 国际站：Ginsenoside Rf

产品活性：Ginsenoside Rf 是人参根的一种微量成分。 Ginsenoside Rf 抑制 N 型 Ca²⁺ 通道。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：Calcium Channel  |  Endogenous Metabolite

结构分类：萜类  |  三萜

来源：植物  |  五加科  |  人参

In Vitro: Ginsenoside Rf is a saponin, which is present in only trace amounts within ginseng. At saturating concentrations, Ginsenoside Rf rapidly and reversibly inhibits N-type, and other high-threshold, Ca²⁺ channels in rat sensory neurons to the same degree as a maximal dose of opioids. The effect is dose-dependent (half-maximal inhibition: 40 μM) and it is virtually eliminated by pretreatment of the neurons with pertussis toxin, an inhibitor of G(o) and Gi GTP-binding proteins. Ginsenoside Rf also inhibits Ca²⁺ channels in the hybrid F-11 cell line.

In Vivo: Since inhibition of Ca²⁺ channels in sensory neurons contributes to antinociception by opioids, analgesic actions of Ginsenoside Rf are tested. Dose-dependent antinociception is found by systemic administration of Ginsenoside Rf in mice using two separate assays of tonic pain: in the acetic acid abdominal constriction test, the ED₅₀ is 56±9 mg/kg, a concentration similar to those reported for aspirin and acetaminophen in the same assay; in the tonic phase of the biphasic formalin test, the ED₅₀ is 129±32 mg/kg.

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