Hydroxysafflor yellow A羟基红花黄色素

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Hydroxysafflor yellow A

CAS No. : 78281-02-4

MCE 国际站：Hydroxysafflor yellow A

产品活性：Hydroxysafflor yellow A (Safflomin A) 是一种可从中药红花中分离出的黄酮类天然产物。Hydroxysafflor yellow A 可通过自噬途径抑制细胞增殖促进细胞凋亡。Hydroxysafflor yellow A 有抗炎、抗氧化和抗肿瘤作用。Hydroxysafflor yellow A 可用于心血管疾病的研究。

研究领域：Others  |  Apoptosis  |  Autophagy

作用靶点：Others  |  Apoptosis  |  Autophagy

In Vitro: Hydroxysafflor yellow A (10 μM, 24 h) Inhibition of LPS-induced proliferation and migration of vascular smooth muscle cells by toll-like receptor-4 pathway.
Hydroxysafflor yellow A (0.01-10 mg/L, 4-96 h) can promote the expression of fat-soluble specific enzyme HSL by increasing the activity of HSL promoter and inhibit the proliferation and adipogenesis of 3T3-L1 preadipocytes.
Hydroxysafflor yellow A (1-100 μM), 12-24 h) decreases LPS-induced EC inflammatory damage by inhibiting p38 MAPK phosphorylation, NF-κB activation, high expression of inflammatory factors and leukocyte adhesion to EC.
Hydroxysafflor yellow A (20-160 μM, 24-48 h) inhibits cell proliferation and promotes apoptosis by blocking the autophagy flux in liver cancer cells.

In Vivo: Hydroxysafflor yellow A (2.5 or 10 mg/kg/day, intraperitoneal injection for 6 weeks) protects the liver from long-term alcohol damage by enhancing antioxidant capacity and inhibiting TGF-β1 expression.
Hydroxysafflor yellow A (30, 48, 76.8 mg/kg, intraperitoneal injection) has a protective effect on inflammatory damage in rats with chronic obstructive pulmonary disease by reducing NF-κB and p38MAPK signal transduction.
Hydroxysafflor yellow A (1.135, 2.25 mg/kg, intraperitoneal injection) can inhibit tumor growth and block autophagy of liver cancer cells in tumor models of nude mice.

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