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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
DL-Tetrahydropalmatine
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2934-97-6
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥218.0 |
| 规格： | 10 mg | 产品价格： | ￥350.0 |
| 规格： | 50 mg | 产品价格： | ￥770.0 |
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Tetrahydropalmatine
CAS No. : 2934-97-6
MCE 国际站：Tetrahydropalmatine
产品活性：Tetrahydropalmatine 可用于缓解疼痛的研究。Tetrahydropalmatine 通过抑制大鼠杏仁核的多巴胺释放来抑制癫痫发作。
研究领域：GPCR/G Protein | Neuronal Signaling | Apoptosis
作用靶点：Dopamine Receptor | Apoptosis
In Vivo: Tetrahydropalmatine (THP), an active component isolated from corydalis (a Chinese herbal medicine), possesses analgesic effects. Picrotoxin treatment alone has a significant effect on the following activity measure: there is an increase in horizontal motion time (HMT), vertical motion time (VMT), clockwise turnings (CT), anticlockwise turning (ACT) and a decrease in freezing time (FT). Tetrahydropalmatine treatment alone causes a decrease in HMT, VMT and total distance traveled (TDT), but an increase in FT. Pretreatment of rats with an i.p. dose of 10 mg/kg or 15 mg/kg of Tetrahydropalmatine significantly attenuates the Picrotoxin-induced enhancement in HMT, VMT, CT, ACT and TDT, as well as reduction in FT. Another 48 rats under urethane anesthesia are randomly divided into six groups, each of eight rats. The s.c. injection of Picrotoxin causes an increase in amygdaloid release of dopamine (DA), while i.p. injection of Tetrahydropalmatine at 10 mg/kg has an insignificant effect on amygdaloid release of DA. Again, the Picrotoxin-induced increase in amygdaloid release of DA is significantly attenuated by pretreatment with Tetrahydropalmatine. The Picrotoxin-induced augmented amygdaloid release of DA is almost completely abolished by pretreatment with Tetrahydropalmatine 30 min before s.c. injection of Picrotoxin.
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文献和实验科草本博物，药用其块茎。又名玄胡、元胡。能活血散瘀、行气止痛。《 本草纲目 》中曾记载“治一身上下诸痛，用之中的，妙不可言”。经研究发现所含延胡索乙素有镇痛作用。它是消旋四氢巴马汀（dl-tetrahydropalmatine），有效部分为左旋体，即罗通定（rotundine）。 口服延胡索乙素及罗通定吸收良好，镇痛作用较解热镇痛药强。研究证明其镇痛作用与脑内阿片受体无关。口服延胡索乙素100～200mg，10～30分钟出现镇痛
索乙素及罗通定 延胡索（Corydalis ambigua）为罂粟科草本博物，药用其块茎。又名玄胡、元胡。能活血散瘀、行气止痛。《 本草纲目 》中曾记载“治一身上下诸痛，用之中的，妙不可言”。经研究发现所含延胡索乙素有镇痛作用。它是消旋四氢巴马汀（dl-tetrahydropalmatine），有效部分为左旋体，即罗通定（rotundine）。 口服延胡索乙素及罗通定吸收良好，镇痛
（fortanodyn）60mg/次，3～4次/日，口服。50mg/次，皮下注射。 纳洛酮（naloxone）0.4～0.8mg/次,肌内注射或静脉注射。 硫酸延胡索乙素（tetrahydropalmatine sulfate）100～150mg/次，3次/日，口服。60～100mg/次，皮下注射。 盐酸罗通定（rotundine hydrochloride）60～100mg/次。3次/日，口服。 硫酸罗通定（rotundine sulfate）60mg/次，皮下注射。
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