In Vitro: 9-Aminoacridine has a strong antimicrobial effect on K. pneumoniae, with MICs from 8 to 16 μg/mL. 9-Aminoacridine (0-64 μg/mL) shows moderate cytotoxicity to normal (LO2, HK2, HMC3) and tumor (HepG2, 786-O, U251) human cell lines, but when used as a RIF adjuvant, the reduced dosage of 9-Aminoacridine further diminishes its toxicity.
In Vivo: 9-Aminoacridine (Aminacrine; 15 mg/kg; subcutaneously) with a single dose decreases the abscess area in the skin subcutaneous abscess mice model.