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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
Litarex tetrahydrate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
6080-58-6
- 规格：
10 mM * 1 mL/1 g/5 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥110.0 |
|---|---|---|---|
| 规格： | 1 g | 产品价格： | ￥100.0 |
| 规格： | 5 g | 产品价格： | ￥180.0 |
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Lithium citrate tetrahydrate
CAS No. : 6080-58-6
MCE 国际站：Lithium citrate tetrahydrate
产品活性：Lithium citrate (Litarex) tetrahydrate 是藤黄果的主要活性成分。Lithium citrate tetrahydrate 可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ，并具有减肥效果。Lithium citrate tetrahydrate 有效抑制结石形成并抑制 HIF，具有抗氧化，抗炎和抗肿瘤作用。
研究领域：Metabolic Enzyme/Protease | Anti-infection
作用靶点：ATP Citrate Lyase | Bacterial | HIF/HIF Prolyl-Hydroxylase | Endogenous Metabolite
In Vitro: Lithium citrate tetrahydrate shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Lithium citrate tetrahydrate can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Lithium citrate tetrahydrate suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells.
In chicken hepatocytes, Lithium citrate tetrahydrate decreases the accumulation of lipid droplets and accelerated energy metabolism. Lithium citrate tetrahydrate protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions.
In Vivo: Lithium citrate (100-200 mg/kg) tetrahydrate treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Lithium citrate tetrahydrate. Lithium citrate tetrahydrate attenuates the oxidative stress induced by calcium oxalate crystallization. Lithium citrate tetrahydrate has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. In addition, Lithium citrate tetrahydrate alleviates tubular injury and apoptosis caused by calcium oxalate crystals.
The administration of Lithium citrate tetrahydrate can suppress body weight gain and fat accumulation in animals.
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文献和实验or disodium citrate. The buffer may be stored for years at +4°C in the dark. - Buffer-saturated phenol, pH 7.0-8.0 (GIBCO/Life Technologies). - Chloroform-isoamyl alcohol mix (24:1). - 96% ethanol. - 80% ethanol. - 12 M lithium chloride
Histological fixatives 组织固定剂和固定方法
9% aqueous NaCl) as formalin pigment is avoided. Specimens may be stored in this fluid. The solution is isotonic. Michel's fixative for immunoflourescence - fixation time 24-48 hours. Buffer : 0.81g potassium citrate 0.0625g N
for immunoflourescence - fixation time 24-48 hours. Buffer : 0.81g potassium citrate 0.0625g N-ethylmaleimide - HANDLE WITH CARE! 0.123g magnesium sulphate 100mls distilled water Before use add 55g ammonium sulphate and allow
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