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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, protect from light
- 英文名：
Sch-6783; SRG-95213
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
364-98-7
- 规格：
10 mM * 1 mL/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥500.0 |
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Diazoxide
CAS No. : 364-98-7
MCE 国际站：Diazoxide
产品活性：Diazoxide (Sch-6783) 是一种 ATP 敏感性的钾离子通道 (potassium channel) 激活剂，有潜力用于高胰岛素血症的研究。
研究领域：Membrane Transporter/Ion Channel | Autophagy
作用靶点：Potassium Channel | Autophagy
In Vitro: Diazoxide (Sch-6783) has a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia. Diazoxide has powerful protective properties against cardiac ischemia.
?Diazoxide (Sch-6783) could protect NSC-34 neurons against the main sources of neurodegenerative damage. Diazoxide increases Nrf2 nuclear translocation in NSC-34 motoneurons and prevents endogenous oxidative damage.
In Vivo: Diazoxide (Sch-6783) attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels.
Treatment with Diazoxide (Sch-6783) in wild-type mice decreases intraocular pressure (IOP) by 21.5±3.2% with an absolute IOP reduction of 3.9 ± 0.6 mm Hg.
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文献和实验，将DMSO换成了NaOH，结果无统计学差异，原本看到的二氮嗪改善学习记忆能力竟是DMSO的作用！而二氮嗪刚好是“mitochondrial ATP-sensitive K+ channel opener”。而其他文章并未看到这种协同作用。所以初步怀疑是干预药的问题。具体文献参照： 1.Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain
激活了调节毛发杆蛋白的特殊基因而促进毛发杆的生长和成熟，故此药可作为治疗（男性）脱发药。 二氮嗪 二氮嗪（diazoxide，氯苯甲噻嗪），直接舒张血管平滑肌而降压，和米诺地尔一样，其降压机制部分是通过激活平滑肌细胞的I K(ATP) （ATP）所中介的钾通道，促进钾外流，使胞膜超极化，Ca 2+ 通道失活，Ca 2+ 内流减少。 临床上主要作静脉注射用，用于
）10～20mg/次，3～4次/日，口服,以后每周增加剂量10～20mg，每日剂量有用至120mg者。 盐酸肼屈嗪（hydralazine hydrochloride）10～25mg/次，3次/日，口服。 二氮嗪（diazoxide）300mg快速静脉注射，溶液碱性极强，避免漏至血管外。 米诺地尔（minoxidil）2.5mg/次，2次/日，口服，逐渐增至5～10mg/次，2次/日。 硝普钠（sodium nitroprusside）50mg临用时以5%葡萄
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