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- 2025年07月15日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CL-82204
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
36330-85-5
- 规格：
10 mM * 1 mL/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥500.0 |
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Fenbufen
CAS No. : 36330-85-5
MCE 国际站：Fenbufen
产品活性：Fenbufen (CL-82204) 是一种具有口服活性的非甾体抗炎化合物 (NSAID)，具有镇痛、解热作用。Fenbufen 在各种动物模型中都有强大的活性，包括角叉菜素水肿、紫外线红斑、佐剂性关节炎等。Fenbufen 对 COX-1 和 COX-2 具有抑制活性，其 IC50 分别为 3.9 μM 和 8.1 μM。Fenbufen 具有 caspases (caspase-1, 3, 4, 5, 9) 抑制活性 。
研究领域：Immunology/Inflammation | Apoptosis
In Vitro: Fenbufen (100-500 μM) improves the viability of apoptotic THP-1 cells treated with 25 μM Nigericin (HY-127019).
In Vivo: Fenbufenmay (1200 mg/kg; feed) does not cause gastric ulceration whilst inducing a near maximal inhibition of prostaglandin release in rats.
Fenbufenmay (1200 mg/kg; p.o.; diet; for 10 days) blocks the hypertrophy of the heart but not that of the skeletal muscles.
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