Phenazopyridine盐酸非那吡啶,136-40-3

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Phenazopyridine hydrochloride

CAS No. : 136-40-3

MCE 国际站：Phenazopyridine hydrochloride

产品活性：Phenazopyridine 是竞争性的 SARM1 抑制剂， IC₅₀ 为 145 μM。Phenazopyridine 是 TRPM8 拮抗剂。Phenazopyridine 具有局部麻醉/止痛作用。Phenazopyridine 用于缓解膀胱炎和尿道炎等疾病的疼痛症状。Phenazopyridine 还可以用于创伤性脑损伤、周围神经病变和神经退行性疾病的研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：TRP Channel

In Vitro: Phenazopyridine (10-30 μM; 12 h) increases mRNA expression of RPS23RG1 in both human SHSY5Y and mouse N2a cells.
Phenazopyridine (5-50 μM; 2 min) inhibits menthol induced (50 μM) TRPM8 response in a dose-dependent and reversible manner in HEK293 cells with an IC₅₀ of 9.6 μM.

In Vivo: Phenazopyridine (15 m/kg; Intracerebroventricularly injection; Once daily for 2 weeks) improves some AD-related cognitive impairment and pathology in Alzheimer's disease (AD) APP/PS1 mice by promoting the expression of Rps23rg1.
Phenazopyridine (0.1-3 mg/kg; i.v.; Single dose) can inhibit mechanosensitive Aδ- fibers, but has no inhibitory effect on C-fibers in Sprague - Dawley rats.

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