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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
132-60-5
- 规格：
10 mM * 1 mL/1 g/5 g/10 g/25 g/50 g/100 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥110.0 |
|---|---|---|---|
| 规格： | 1 g | 产品价格： | ￥100.0 |
| 规格： | 5 g | 产品价格： | ￥300.0 |
| 规格： | 10 g | 产品价格： | ￥450.0 |
| 规格： | 25 g | 产品价格： | ￥900.0 |
| 规格： | 50 g | 产品价格： | ￥1530.0 |
| 规格： | 100 g | 产品价格： | ￥2600.0 |
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Cinchophen
CAS No. : 132-60-5
MCE 国际站：Cinchophen
产品活性：Cinchophen 是一种具有口服活性的非甾体抗炎试剂 (anti-inflammatory agent)，具有抗菌作用。Cinchophen 可用于关节炎和某些肝脏疾病的研究。
研究领域：Anti-infection
作用靶点：Bacterial
In Vivo: Cinchophen (oral gavage; 25-44 mg/kg; twice daily) combines prednisolone ( 0.125-0.220 mg/kg; twice daily) for 14 days is effective in dogs with osteoarthritis and well tolerated. The combination exhibits significantly improved lameness, weight bearing, joint mobility and stiffness scores and is similar in clinical efficacy to phenylbutazone.
The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) is tested. Cinchophen administation at a dose rate of 12.5 mg/kg intravenously exhibits a volume of distribution (Vd area) of 0.13 L/kg, shows a clearance rate (Cl) of 0.15 L/h and a half-life (t1/2β) of 7.92 hours. The plasma concentration time curve (AUC0-∞) is 1187.0 μ/ml.h in dogs.
Cinchophen administation (oral gavage; 12.5 mg/kg; single dose) exhibits a mean maximum plasma concentration (Cmax) of 77.75 μg/ml and the time of Cmax (tmax) is 2.76 hours. The plasma concentration time curve (AUC0-∞) is almost as large following oral as intravenous administration indicating an oral bioavailability (F) of 87.21%.
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文献和实验-150(145) 21.81 兔1.36-2.26kg 28.4-85.1/kg(150) 60-140/kg(300) 132.609.75 金黄地鼠(成
0.351.08±0.15(0.8-2.05)132±16.4110±12.5(80.0-165)15.0±4.9013.9±3.20(5.00-23.9)0.55±0.110.42±0.10(0.20-0.90)147±2.20146±1.90(139-153)4.54±1.104.42±0.20(3.60-5.20)114±1.15111±1.20(103-121)21.8±3.6022.2±2.91(14.6-29.4)4.40±1.003.60±0.50(2.60-5.60)10.2±0.429
Immunofluorescence on ultrathin resin sections
for 10 min. Remove blocking buffer, add 25 µl of the primary antibody solution per coverslip (with a final concentration in the range of 1-5 µg specific IgG/ml) and incubate for 30 -60 min. Wash 5 times with buffer
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