PU-WS13,1454619-14-7

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PU-WS13

CAS No. : 1454619-14-7

MCE 国际站：PU-WS13

产品活性：PU-WS13 是一种选择性的 Grp94 抑制剂，EC₅₀ 值为 0.22 μM。

研究领域：Cell Cycle/DNA Damage | Metabolic Enzyme/Protease

作用靶点：HSP

In Vitro: PU-WS13 is a Grp94 inhibitor, with an EC₅₀ of 0.22 μM. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC₅₀s of 27.3, 41.8 and 7.3 μM, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells.

相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Endoplasmic Reticulum Stress Compound Library | Pyroptosis Compound Library | Cytoskeleton Compound Library | Anti-Breast Cancer Compound Library | Tamoxifen | Tanespimycin | Palmitic acid | Geldanamycin | Ganetespib | Rocaglamide | Luminespib | VER-155008 | Gamitrinib TPP hexafluorophosphate | HA15 | Alvespimycin hydrochloride | Arimoclomol maleate | Apoptozole | Onalespib | Pimitespib | Grp94 Inhibitor-1 | HSP27 inhibitor J2 | Pifithrin-μ | BIIB021 | KNK437 | MKT-077 | HSF1A | JG-98 | KRIBB11 | NVP-HSP990 | Debio 0932 | Paeoniflorin | ML346 | TRC051384

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