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Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg/200 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥758.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥250.0 |
| 规格： | 5 mg | 产品价格： | ￥550.0 |
| 规格： | 10 mg | 产品价格： | ￥790.0 |
| 规格： | 50 mg | 产品价格： | ￥2420.0 |
| 规格： | 100 mg | 产品价格： | ￥4110.0 |
| 规格： | 200 mg | 产品价格： | ￥6520.0 |
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SR9243
CAS No. : 1613028-81-1
MCE 国际站：SR9243
产品活性：SR9243 是 liver-X-receptor (LXR) 的反向激动剂，能够诱导 LXR-辅阻遏物相互作用。
研究领域：Metabolic Enzyme/Protease | Vitamin D Related/Nuclear Receptor
作用靶点：LXR
In Vitro: SR9243 specifically targets LXR and downregulates LXR-mediated gene expression, dose-dependently suppresses LXRα- and LXRβ-dependent transcription at nanomolar concentrations, and potently inhibits LXR-driven luciferase activity in cultured cancer cells. SR9243 potently reduces cancer cell viability at nanomolar concentrations (IC50 appr 15-104 nM) in prostate (PC3 and!DU-145), colorectal (SW620 and HT29), and lung (HOP-62 and NCI-H23) cancer cell lines. And the colony-forming capacity of cancer cells is also significantly loared by SR9243 in a dose-dependent manner. SR9243 is a potent inhibitor of lipogenic gene expression that selectively kills cancer cells by depleting intracellular lipids. Combination of cancer cell media with oleate, stearate, and palmitate in combination completely rescues cancer cell viability in cancer cells. Fatty acid supplementation also rescues the viability of SW620 cells in which glycolysis is substantially disrupted.
In Vivo: SR9243 is able to profoundly inhibit tumor glycolysis, lipogenesis, and induce apoptotic cancer cell death without promoting weight loss in vivo. SR9243 inhibits tumor growth without profoundly repressing glycolytic gene expression, and inhibits tumor growth and lipogenesis without hepatotoxicity or inflammation in vivo.
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文献和实验Purification of SR Protein Splicing Factors
In recent years, the SR protein family of precursor messenger RNA splicing factors has emerged as a key player in the assembly of the spliceosomal machinery onto pre-mRNA. The SR proteins are essential splicing factors and different family
清道夫受体 (scavenger receptor ， SR) 是固有免疫中一类重要的模式识别受体，分为多种类型，主要为SRA和SRB，可能还包括SRC等，其中各自又由不同的分子组成。 注：M。：单核细胞；P1t：血小板；LTA：淋巴毒素。；LDL：低密度脂蛋白。MARCO：带胶原结构的巨噬细胞受体；LOX-1：凝集素样氧化低密度脂蛋白受体；SREC：内 皮细胞表达的清道夫受体。 SPA为三聚体缠绕的糖蛋白跨膜分子，各带有5个不同的结构域。其中胶原样结构
1、目的：为使仪器正常运转，保证结果的可靠性，特制定此操作规程。2、适用范围：化验室3、责任者：化验员应严格遵照该操作规程，QC主管负责监督本规程的实施。4、定义：无5、安全注意事项：无6、操作规程6.1.准备6.1.1.控制水槽水位，使之高于溶出杯中介质的高度。6.1.2.开启溶出仪，自动取样器及打印机电源。6.1.3.排除对试验有影响振动干扰。6.1.4.调节高度：将桨或蓝的底部轻轻置于杯的底部，抬起显示面板，垫上标准垫块P或B（P为转桨法，B为转蓝法），放下显示面板，测桨或蓝的底部距杯底
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