DNA Ligase 1 Antibody
Cat#:PL0300744
Isotype:Rabbit Polyclonal IgG
Immunogen:Peptide derived from Hu DNA Ligase 1.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
Eukaryotic DNA ligases are ATP-dependent enzymes that catalyse the joining of single and double-strand DNA breaks, which is an essential final step in DNA replication, recombination and repair. Four biochemically distinct DNA ligases, termed ligases I-IV, have been identified in mammalian cells. DNA ligase I is functionally homologous to the DNA ligase encoded by the Saccharomyces cerevisiae Cdc9 gene. The joining of Okazaki fragments during lagging strand DNA replication in mammalian cells is due to DNA ligase I.
Alternate Names:
DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1; DNLI1_Hu.
Specificity Reaction:Hu, Mo, Rat, Dog, Pig, Cow, Hor
Application Notes:E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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