AF6/Afadin Antibody
Cat#:PL0300480
Isotype:Rabbit Polyclonal IgG
Immunogen:Peptide derived from Hu AF6 (391-430aa).
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
Afadin is a cell-cell adherens junction F-actin binding multidomain protein. Two splice variants of afadin have been described: l-afadin, which is ubiquitously expressed, and the smaller s-afadin, which is abundantly expressed in neural tissue. l-Afadin contains one PDZ domain near its middle followed by three proline-rich and one F-actin-binding region at the carboxyl-terminal. l/s-Afadin is localized to cell-cell junctions and binds several cytoplasmic proteins such as the small GTPase Ras, the tight junction protein ZO-1, and the vinculin binding protein ponsin/SH3P12.
Alternate Names:
p-Afadin(Ser1718); MLLT4; Protein AF6; AF6; Afadin; AFAD_Hu; ALL1-fused gene from chromosome 6 protein; Protein AF-6.
Specificity Reaction:Hu, Mo, Rat, Dog, Pig, Cow, Hor,
Application Notes:E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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