Capicua Antibody
Cat#:PL0306727
Isotype:Rabbit Polyclonal IgG
Immunogen:Peptide derived from human Capicua (1475-1560aa).
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
Capicua is the mammalian ortholog of the drosophilia Cic gene and is part of the HMG-box protein superfamily. Expressed primarily in the fetal brain, Capicua functions as a transciptional repressor and is involved in the development of the nervous system through interaction with the ATXN1 protein. When ATXN1 assembles into stable complexes, it directly binds Capicua, thereby mediating both the activity and expression of Capicua. When Capicua is active, it is able to interact with other developmental proteins to restrict the growth of granule cells and regulate normal neuronal development.
Alternate Names:
Capicua homolog (Drosophila); Cic; CIC; KIAA0306; Protein capicua homolog; CIC_HUMAN.
Specificity Reaction:Hu, Mo, Rat, Dog, Pig, Cow, Hor, , Sheep
Application Notes:E: 1:500-1000 IHC: 1:100-500 IF: 1:100-500 ICC: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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