磷酸化乙酰辅酶A羧化酶1ACCα抗体

Phospho-Acetyl CoA Carboxylase(Ser79) Antibody

Cat#：PL0305931

Isotype:Rabbit Polyclonal IgG

Immunogen：PhosphoPeptide derived from human Acetyl CoA Carboxylase around the phosphorylation site of Ser79.

Purification: Immunogen affinity purified

Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)

Background：

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACC alpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC∫ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACC alpha is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACC alpha maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues.

Specificity Reaction：Hu, Mo, Rat, Dog, Pig, Cow, Hor, Sheep, Guinea Pig

Application Notes:E: 1:500-1000 IHC: 1:100-500 IF: 1:100-500 ICC: 1:100-500

Storage ：

Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.

This product for research use only, not for use in humans, therapeutic or diagnostic procedures.

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