phospho-AMPK alpha 2 (Ser176) Antibody
Cat#:PL0305915
Isotype:Rabbit Polyclonal IgG
Immunogen:PhosphoPeptide derived from human AMPK alpha 2 around the phosphorylation site of Ser176.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Alternate Names:
AMPK alpha 2 (phospho S176); AMPK alpha 2 (phospho Ser176); p-AMPK alpha 2 (S176); p-AMPK alpha 2 (Ser176); p-AMPK2(phospho S176); 5'-AMP-activated protein kinase catalytic subunit alpha-2; AAPK2_HUMAN; AMP activated protein kinase alpha 2 catalytic subunit; AMPK 2; AMPK alpha 2 chain; AMPK subunit alpha-2; AMPKalpha2; PRKAA 2; PRKAA; PRKAA2; Protein kinase AMP activated alpha 2 catalytic subunit.
Specificity Reaction:Hu, Mo, Rat, Pig, Cow, Hor, Sheep
Application Notes:WB: 1:100-500 E: 1:500-1000 IHC: 1:100-500 IF: 1:100-500 ICC: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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