phospho-APC (Ser2054) Antibody
Cat#:PL0305866
Isotype:Rabbit Polyclonal IgG
Immunogen:PhosphoPeptide derived from human APC around the phosphorylation site of Ser2054.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Alternate Names:
APC (phospho S2054); p-APC (phospho S2054); Adenomatous Polyposis Coli; APC; CC1; DP2; DP2.5; DP3; FAP; FPC; GS; Protein APC.
Specificity Reaction:Hu, Mo, Rat, Dog, Pig, Cow, , Sheep
Application Notes: IP:1:20-100 IHC: 1:100-500 IF: 1:100-500 ICC: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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