BAX抗体

BAX Antibody

Cat#：PL0401013

Isotype:Rabbit Polyclonal IgG

Immunogen：peptide corresponding to a sequence at the N-terminus of human Bax.

Purification: Immunogen affinity purified

Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)

Background：

BAX(Bcl-2 Associated X Protein) is a member of the Bcl-2 gene family, it encodes a 21-kDa protein whose association with Bcl-2 is believed to play a critical role in regulating apoptosis. Human BAX gene is located in the q13.3-q13.4 region of human chromosome 19. Bax is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases. It resides in an inactive state in the cytosol of many cells. Bax consists of 9 alpha helices and has extensive amino acid homology with Bcl-2, focused within highly conserved domains I and II. Bax is encoded by six exons and demonstrates a complex pattern of alternative RNA splicing that predicts a 21 kd membrane(alpha) and two forms of cytosolic protein(beta and gamma). BAX and BAK are essential for regulating the number of B cells at both immature and mature developmental stages.

Specificity Reaction：Hu, Mo, Rat

Application Notes:WB: 1:100-500

Storage ：

Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.

This product for research use only, not for use in humans, therapeutic or diagnostic procedures.

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