phospho-arfaptin 2(Ser260) Antibody
Cat#:PL0301367
Isotype:Rabbit Polyclonal IgG
Immunogen:PhosphoPeptide derived from Hu arfaptin 2 around the phosphorylation site of Ser260.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
ARFIP2 is a ubiquitously expressed protein implicated in mediating cross talk between RAC and ARF small GTPases. It has been shown that ARFIP2 binds specifically to GTP-bound ARF1 and ARF6, but binds to Rac-GTP and Rac-GDP with similar affinities. The X-ray structure of arfaptin reveals an elongated, crescent-shaped dimer of 3-helix coiled-coils. Structures of arfaptin with Rac bound to either GDP or the slowly hydrolysable analog GMPPNP show that the switch regions adopt similar conformations in both complexes.
Alternate Names:
ADP ribosylation factor interacting protein 2; Arfaptin 2; ARFIP2; Partner of RAC1; POR1; ARFP2_Hu.
Specificity Reaction:Hu, Mo, Rat, Dog, Cow, Sheep,
Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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