APOE4/Apolipoprotein E4 Antibody
Cat#:PL0301326
Isotype:Rabbit Polyclonal IgG
Immunogen:Peptide derived from Hu APOE4.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. Defects in ApoE are a cause of hyperlipoproteinemia type III due to increased plasma cholesterol and triglycerides levels which are the consequence of impaired clearance of chylomicron and VLDL remnants.
Alternate Names:
APOE4; Apolipoprotein E4; AD2; Alzheimer disease 2 (APOE*E4 associated, late onset); Apo E4; APOE; apoe4; Apolipoprotein E; Apolipoprotein E3; LDLCQ5; LPG; MGC1571.
Specificity Reaction:Hu, Mo, Rat,
Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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