peptide corresponding to a sequence at the C-terminus of human GPR2/CCR10.
亚型:
Rabbit Polyclonal IgG
形态:
液态
保存条件:
保存于-20℃
克隆性:
多克隆
标记物:
无标记(PLlabs可供应生物素、酶、荧光素标记的抗体)
适应物种:
Hu,Mo,Rat
保质期:
按说明书条件可保存1-2年
抗原来源:
见详细说明资料
目录编号:
PL0402130
级别:
超纯
库存:
大量
供应商:
华拓生物
宿主:
Rabbit
应用范围:
WB: 1:100-500
浓度:
1mg/ml
靶点:
CCR10
抗体英文名:
CCR10 Antibody
抗体名:
CCR10抗体
规格:
0.1ml
CCR10 Antibody
Cat#:PL0402130
Isotype:Rabbit Polyclonal IgG
Immunogen:peptide corresponding to a sequence at the C-terminus of human GPR2/CCR10.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
CCR10, C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene. CCR10 is constitutively expressed in skin melanocytes, fibroblasts, and microvascular endothelial cells, and that it is upregulated by IL1B and TNF. Expression was also detected in T cells, Langerhans cells, and peripheral blood mononuclear cells but not in dendritic cells.By fluorescence in situ hybridization, the GPR2 gene is mapped to 17q21.1-q21.3. CCR10 is the receptor for CCL27. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation. expression of CCL27 in normal keratinocytes and its strong upregulation in skin lesions of atopic dermatitis, contact dermatitis, and psoriasis patients. CCR10+ T lymphocytes were detected in lesional but not normal skin of these patients. Flow cytometric analysis showed that CCL27 binds extracellular matrix components and dermal microvascular endothelial cells and fibroblasts and mediates adhesion and transendothelial migration of CCR10+ circulating leukocytes. CCR10 is predominantly expressed on CD4+CLA+(cutaneous lymphocyte antigen), rather than CD8+, circulating T cells.
Alternate Names:
C C chemokine receptor type 10 antibody;CC chemokine receptor 10 antibody;CC CKR 10 antibody;CCR10 antibody;Chemokine(C C motif) receptor 10 antibody;G protein coupled receptor 2 antibody.
Specificity Reaction:Hu,Mo,Rat
Application Notes:WB: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.