peptide corresponding to a sequence at N-terminus of rat HIF-2-alpha.
亚型:
Rabbit Polyclonal IgG
形态:
液态
保存条件:
保存于-20℃
克隆性:
多克隆
标记物:
无标记(PLlabs可供应生物素、酶、荧光素标记的抗体)
适应物种:
Rat
保质期:
按说明书条件可保存1-2年
抗原来源:
见详细说明资料
目录编号:
PL0401106
级别:
超纯
库存:
大量
供应商:
华拓生物
宿主:
Rabbit
应用范围:
WB: 1:100-500 IHC: 500-1000
浓度:
1mg/ml
靶点:
HIF-2α
抗体英文名:
HIF-2α Antibody
抗体名:
HIF-2α抗体
规格:
0.1ml
HIF-2α Antibody
Cat#:PL0401106
Isotype:Rabbit Polyclonal IgG
Immunogen:peptide corresponding to a sequence at N-terminus of rat HIF-2-alpha.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
HIF-2 alpha is also designated EPAS1 whose gene is mapped to 2p21-p16. The predicted mouse protein is 88% identical to human EPAS1. The human EPAS1 gene contains 15 exons and spans at least 120 kb. The positions of the introns within the genomic region encoding the N-terminal bHLH-PAS domains of EPAS1 and AHR are similar, suggesting that the 5-prime ends of the 2 genes may have arisen from a gene duplication event1. Moreover, the predicted protein shares 48% sequence identity with HIF1-alpha, a bHLH-PAS transcription factor that induces EPO gene expression in cultured cells in response to hypoxia. Like HIF1A, EPAS1 binds to and activates transcription from the HIF1A response element derived from the 3-prime flanking region of the EPO gene. EPAS1 is predominantly expressed in highly vascularized tissues of adult humans and in endothelial cells of the mouse adult and embryo. Furthermore, EPAS1 may represent an important regulator of vascularization, perhaps involving the regulation of endothelial cell gene expression in response to hypoxia2. HIF2A is expressed at relatively higher levels in villus sections of placenta and in lung samples compared with other tissues examined3.
Alternate Names:
Basic helix loop helix PAS protein MOP2 antibody;bHLHe73 antibody;Class E basic helix-loop-helix protein 73 antibody;ECYT4 antibody;Endothelial PAS domain containing protein 1 antibody;Endothelial pas domain protein 1 antibody;EPAS1 antibody;EPAS1_HUMAN antibody;HIF 1 alpha like factor antibody;HIF 2 alpha antibody;HIF2-alpha antibody;Hif2a antibody;HLF antibody;Hypoxia inducible factor 2 alpha antibody;Hypoxia inducible factor 2 alpha subunit antibody;Member of PAS protein 2 antibody;Member of pas superfamily 2 antibody;MOP2 antibody;PAS domain-containing protein 2 antibody;PASD2 antibody.
Specificity Reaction:Rat
Application Notes:WB: 1:100-500 IHC: 500-1000
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.