MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO). It blocks the production of H2O2 and increases the cells survival. Polyamine catabolism is one of the major causes of the ROS production of prostate cells in general and androgen-induced enhancement of ROS in androgen-dependent CaP cells in particular. Reports suggest that androgen stimulation of prostate cancer results in accumulation of ROS, which lead to progression of cancer, such progression is control by MDL 72527.
性质
Related Categories Bioactive Small Molecule Alphabetical Index, M, 生物活性小分子, 细胞生物学
assay ≥98% (HPLC)
form powder
color light yellow to light brown
solubility H2O: soluble15 mg/mL, clear
storage temp. room temp