M-CSF was initially found in serum, urine or other body fluid. Produced by a number of different cells, M-CSF could selectively stimulate the formation of macrophage colonies, thus became the firstly studied colony-stimulating factor. It is required for the proliferation and differentiation of mononuclear phagocytic cells, and the formation of their colonies, which can secrete G-CSF and GM-CSF, forming a gradually enlarged cytokine network. Meanwhile, M-CSF can stimulate generation of neutrophilic granulocytes from bone marrow, promoting both quantity and function of the cells. Acting on the terminal cells, M-CSF can also boost the function of mononuclear phagocytic cells. 仅供实验室使用。