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产品名称:磷酸化APP淀粉样肽前体蛋白抗体,phospho-Amyloid Precursor Protein (Thr668)
别 名:Amyloid Precursor Protein (phospho T668); Amyloid Precursor Protein (phospho Thr668); p-Amyloid Precursor Protein (phospho T668); APP (Phospho-Thr668); p-APP(Thr668); C31; C80; C83; C99; beta-amyloid precursor protein C-terminus; A4 amyloid protein; A4; AAA; ABETA; ABPP; AD 1; AD1; Alzheimer disease 1; Alzheimer disease; Alzheimer's disease amyloid protein; Amyloid beta (A4) precursor protein; Amyloid beta A4 protein; Amyloid beta A4 protein precursor isoform b; Amyloid beta A4 protein precursor isoform c; Amyloid beta A4 protein precursor isoform a; Amyloid beta A4 protein precursor isoform b; Amyloid beta A4 protein precursor isoform c; Amyloid beta protein; Amyloid beta-peptide; Amyloid of aging and alzheimer disease; APP; APP I ; APPI; Beta amyloid peptide; Cerebral vascular amyloid peptide; CTFgamma; CVAP; Human mRNA for amyloid A4 precursor of Alzheimer's disease; PN 2; PN II; PN2; PreA4; Protease nexin II; A4_HUMAN.
产品类型:磷酸化抗体
研究领域:细胞生物 神经生物学 信号转导 细胞凋亡 激酶和磷酸酶 Alzheimer's
抗体来源:Rabbit
克隆类型:Polyclonal
交叉反应:Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量:3.4-9/83kDa
细胞定位:细胞核 细胞浆 细胞膜 细胞外基质
性 状:Lyophilized or Liquid
浓 度:1mg/1ml
免 疫 原:KLH conjugated Synthesised phosphopeptide derived from human APP around the phosphorylation site of Thr668
亚 型:IgG
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
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HLA(sh-haling)290 大白鼠PRDM2/RIZ1 锌指蛋白RIZ1抗体
HLA(sh-haling)291 大白鼠PRMT6 组蛋白精氨酸甲基6抗体
HLA(sh-haling)292 大白鼠PRSS8 丝氨酸蛋白酶8抗体
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文献和实验意识。 想了解 Aβ,我们还要从它的前体蛋白 APP 说起。 APP 全称淀粉样前体蛋白,英文名称为 Amyloid Precursor Protein。人类的 APP 基因位于 21 号染色体长臂,包含至少 18 个外显子。APP 分布广泛,mRNA 及其蛋白在脑、胸腺、心、肌肉、肺、肾脏、脂肪组织、肝、脾、皮肤及肠道等组织均有表达 [1]。APP 属Ⅰ型跨膜糖蛋白,分子量约 110~130kD,具有较大的膜外 (氨基端) 结构域和较小的胞质尾区 (胞内羧基端)[1]。APP 的胞外
Interaction of the Presenilins with the Amyloid Precursor Protein (APP)
the deposition of amyloid Aβ peptide. The latter is released from its cognate amyloid precursor protein (APP) by a two-step proteolytic conversion: first, proteolysis of APP by β-secretase, which releases the N-terminus of Aβ, and second, conversion
Posttranslational Modifications of the Amyloid Precursor Protein: Glycosylation
Many studies have demonstrated the importance of amyloid precurser protein (APP) in the pathogenesis of Alzheimer’s disease. Nonetheless, the exact mechanism by which APP contributes to the pathogenesis of Alzheimer’s disease is still not clear
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