HeLa人宫颈癌细胞
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HeLa人宫颈癌细胞

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  • 中乔新舟已认证
  • 中国
  • ZQ0068
  • 2025年12月12日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 英文名

      HeLa

    • 库存

      大量

    • 细胞类型

      细胞系

    • 品系

      human

    • 相关疾病

    • 免疫类型

    • 细胞形态

      咨询销售

    • 运输方式

      T25瓶运输

    • 年限

      5-10年

    • 生长状态

      贴壁生长

    • 规格

      5 x 10^5 cells/vial

    产品名称

    Hela人宫颈癌细胞

    货号

    ZQ0068

    产品介绍

    HeLa细胞系是从一位31岁黑人女性患者的宫颈癌组织中分离和培养出来的,这是世界上第一株体外培养的人类永生化细胞株。角蛋白免疫过氧化物酶染色阳性。 据报道,p53表达水平低,pRB(成视网膜细胞瘤抑制因子)表达水平正常。Hela 为重大研究进展做出了重大贡献,并继续在世界各地的实验室中发挥着关键作用。
    1951 年,亨利埃塔·拉克斯 (Henrietta Lacks) 是一位五个孩子的年轻母亲,因阴道出血前往约翰·霍普金斯医院求医,霍华德·琼斯 (Howard Jones) 医生在她的子宫颈上发现了一个严重的恶性肿瘤。当时,约翰霍普金斯大学医学研究所是为数不多的为贫困非裔美国人提供医疗服务的机构之一。亨利埃塔·拉克斯 (Henrietta Lacks) 接受了针对宫颈癌的镭治疗,这是当时先进的治疗方法。在她的治疗期间,进行了活组织检查,并将她的癌细胞样本送往乔治·奥托·盖伊博士的实验室。盖伊博士一直试图培养来自不同背景的宫颈癌患者的细胞,但一直没有成功,直到亨利埃塔的细胞成为第一个持续增殖的细胞,这一发现使它们与之前的所有样本区分开来。后来发现亨丽埃塔·拉克斯的宫颈癌是由人乳头瘤病毒(HPV)引起的。 HPV 是一种常见病毒,可导致宫颈癌等疾病。对 HeLa 细胞的研究极大地促进了了解 HPV 在宫颈癌中的作用,从而促进了预防性 HPV 疫苗的开发,这对降低 HPV 相关癌症的发病率产生了深远的影响。
    该细胞以 Henrietta Lacks 的名字缩写命名为“HeLa”细胞,从此在医学研究中发挥了重要作用。它们使科学家能够研究癌细胞的生长、各种物质的影响以及病毒的作用,从而极大地促进了医学进步,包括开发脊髓灰质炎和 COVID-19 疫苗,而无需担心直接人体实验的伦理问题。HeLa细胞因其高转染效率和对病毒感染的敏感性而被广泛用于基因功能研究、重组蛋白生产和基因治疗。在研究病毒行为(包括复制和发病机制)方面发挥着关键作用,并通过表达病毒蛋白并帮助开发诊断测试和疫苗,在乙型肝炎研究中发挥了关键作用,从而显着推进了全球卫生措施。
    Hela细胞仍然是正在进行的医学和科学研究的宝贵资源。 HeLa 细胞和其他永生细胞系的重要性怎么强调都不为过,因为它们继续塑造医学和传染病研究领域,并且代表了 Henrietta Lacks 的持久遗产及其对科学进步的贡献。

     

    【注意事项】:该细胞代谢旺盛,建议及时换液或传代。

    种属

    性别/年龄

    女/31岁

    组织

    子宫颈

    疾病

    宫颈腺癌

    细胞类型

    肿瘤细胞

    形态学

    上皮细胞

    生长方式

    贴壁

    倍增时间

    大约31.2~48小时

    培养基和添加剂

    EMEM(含NEAA)(品牌:中乔新舟 货号:ZQ-300)++10%FBS(品牌:中乔新舟 货号:ZQ500-A)+1%P/S(中乔新舟 货号:CSP006)

    推荐完全培养基货号

    ZM0068

    生物安全等级

    BSL-2

    STR位点信息

    Amelogenin: X

    CSF1PO: 9,10

    D13S317: 12,13.3

    D16S539: 9,10

    D5S818: 11,12

    D7S820: 8,12

    TH01: 7

    TPOX: 8,12

    vWA: 16,18

    培养条件

    95%空气,5%二氧化碳;37℃

    抗原表达/受体表达

      ***

    基因表达

      ***

    保藏机构

    ATCC; CCL-2 ATCC; CRM-CCL-2 ATCC; CRL-7923 BCRC; 60005 BCRJ; 0100 DSMZ; ACC-57 ECACC; 08011102 ECACC; 93021013

    供应限制

    仅供科研使用

    上海中乔新舟生物科技有限公司成立于2011年,历经十多年发展,主要专注于细胞生物学产品的研究和开发,专注于为药企、各类科研机构及CRO企业提供符合标准规范的细胞培养服务、细胞培养基、细胞检测试剂盒、细胞培养试剂,胎牛血清和细胞生物学技术服务等。

    公司一直致力于为高等院校、研究机构、医院、CRO及CDMO企业提供细胞培养完整解决方案,这些产品旨在满足细胞培养的多样需求,确保实验和研究的有效进行。引用中乔新舟(ZQXZBIO)产品和服务的文献超数千篇。

    HeLa人宫颈癌细胞

    产品服务

    细胞资源:原代细胞、细胞株、干细胞、示踪细胞、耐药株细胞、永生化细胞等基因工程细胞。

    试剂产品:胎牛血清、完全培养基(适用于原代细胞及细胞株)、无血清培养基、基础培养基、细胞转染试剂、重组因子、胰酶和双抗等等细胞培养所有实验相关产品。

    技术服务:稳转株构建、原代细胞分离、特殊培养基定制服务、细胞检测等。

    HeLa人宫颈癌细胞

    目前产品已经畅销国内30多个省市,与客户建立长期的合作伙伴关系,共同实现成功。全体员工将不懈努力,继续为科研人员提供优良的产品和服务,致力成为全球细胞培养领域的参与者。

    HeLa人宫颈癌细胞

    企业愿景

    致力于成为国内细胞培养基产业的佼佼者,生物医药领域上游原材料的优良提供商。

    企业使命

    成长为专业细胞系及原代细胞培养供应商、专业细胞培养基及培养试剂生产商。

    企业荣誉

    HeLa人宫颈癌细胞

    HeLa人宫颈癌细胞

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    图标文献和实验
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    Skloot R.L.
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    Javitt G.H.
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    Mol. Cell. Proteomics 11:M111.011429-M111.011429(2012)

     

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    Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins.
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    Vazquez-Mena O., Medina-Martinez I., Juarez-Torres E., Barron V., Espinosa A., Villegas-Sepulveda N., Gomez-Laguna L., Nieto-Martinez K., Orozco L., Roman-Bassaure E., Munoz Cortez S., Borges Ibanez M., Venegas-Vega C.A., Guardado-Estrada M., Rangel-Lopez A., Kofman S., Berumen J.
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    Pultarova T.
    HeLa cells: immortal space travellers.
    Space Saf. Mag. 7:10-12(2013)

     

     

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    Malerod H., Graham R.L.J., Sweredoski M.J., Hess S.
    Comprehensive profiling of N-linked glycosylation sites in HeLa cells using hydrazide enrichment.
    J. Proteome Res. 12:248-259(2013)


     

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