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- 详细信息
- 文献和实验
- 技术资料
- 浓度:
1mg/ml
- 应用范围:
科学研究
- 宿主:
Rabbit
- 适应物种:
Human,Mouse,Rat,Chicken,Dog,Cow,Rabbit,Sheep
- 标记物:
PE HRP Gold Cy5.5 Cy7 RBITC PE-CY5.5 PE-CY7 APC FITC Cy3 Cy949
- 克隆性:
Polyclonal
- 保存条件:
-20℃
- 形态:
液态/冻干粉
- 亚型:
IgG
- 免疫原:
KLH conjugated synthetic peptide derived from human/mouse/Rat
- 规格:
25 ug
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文献和实验Biochemical Analysis of the Native TRAIL Death-Inducing Signaling Complex
receptor 1 (TRAIL-R1/DR4), TRAIL-R2 (KILLER/APO-2/DR5/TRICK), CD95 (Fas, APO-1), or TNF receptor 1 (TNF-R1), this complex is termed death-inducing signaling complex (DISC). The compositions of the various DISCs have been intensively studied in the last 12
/Apol(23%同源)的同源序列。TRAIL/Ap02L属于Ⅱ型膜蛋白,但可以被水解后释放,存在于各种组织中。TRAIL有两个细胞膜受体:TRAIL-R1(DR4)和TRAIL-R2(DR5)。这两个受体都有细胞内的死亡结构域,可以传递凋亡信号。此外,还有两个缺陷受体(decoyreceptor):DcRl和DcR2,也被称之为TRAIL-R3和TRAIL-R4。 尽管Ap02/TRAIL的生物活性与诱导凋亡有关,但其确切的生理功能并不十分清楚。小鼠Ap02L/TRAIL基因敲除模型显示
Methods to Analyze Cellular Necroptosis
Necroptosis is a mechanism of necrotic cell death induced by external stimuli in the form of death domain receptor (DR) engagement by their respective ligands, TNF-alpha, Fas ligand (FasL) and TRAIL, under conditions when apoptotic cell death
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