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- 详细信息
- 技术资料
- 形态:
液态/粉状
- 保存条件:
-20℃保存
- 克隆性:
多克隆
- 标记物:
见说明书
- 适应物种:
人,大鼠,小鼠,兔
- 宿主:
Goat,Rabbit,Mouse
- 应用范围:
科研使用
- 浓度:
1mg/1ml
- 靶点:
来电咨询
- Bcl-XL Monoclonal Antibody保存于运输说明:
- Store at -20°C
- 详细信息:
-
Description 
Monoclonal Antibody against Bcl-XL Clone 
2H12 Form 
Ascites Host 
Mouse Species Reactivity 
Mouse, Human, Rat IsoType 
Bcl-XL Monoclonal AntibodyIgG2a [Ab] 
3-5 mg/mL Specificity 
Bcl-2, Bcl-XL, and Bax are members of the bcl-2 family of proteins that regulate apoptosis. Some family members like Bcl-2, Bcl-XL inhibit apoptosis and other members such as Bax and Bcl-XS function to promote apoptosis. It appears that homodimerization and heterodimerization between the various death promoting and death inhibiting family members regulate the activation of caspases that in turn execute the cell death program.
Anti-Bcl-XL was generated by immunizing mice with a KLH-conjugated peptide having a sequence corresponding to amino acids 3-14 shared by both human and murine Bcl-XL (CQSNRELVVDFLS).Uses 
This antibody is effective in immunoblotting and immunoprecipitation. Suggested Working Dilution 
Bcl-XL Monoclonal AntibodyThe optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:500*
Notes 
*Predicted MW = 27kD Storage 
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For short-term storage keep antibody at 4°C. Store at -20°C for long term, you may add 20-50% glycerol for cryopreservation. References 
Hsu YT, Youle RJ. Bax in Murine Thymus is a soluble monomeric protein that displays differential detergent induced conformations. J. Biol. Chem. 273(17):10777-10783, 1998.
Hsu YT, Youle RJ. Nonionic detergents induce Dimerization among members of the Bcl-2 family. J. Biol. Chem. 272(21):3829-13834, 1997.Warranty/Conditions 
Covance products may not be resold or modified for resale without prior written approval. - Bcl-XL Monoclonal Antibody
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Bcl-XL Monoclonal Antibody
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