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- 详细信息
- 技术资料
- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- 规格:
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥713.0 |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥318.0 |
| 规格: | 5 mg | 产品价格: | ¥700.0 |
| 规格: | 10 mg | 产品价格: | ¥1100.0 |
| 规格: | 25 mg | 产品价格: | ¥1663.0 |
| 规格: | 50 mg | 产品价格: | ¥2480.0 |
| 规格: | 100 mg | 产品价格: | ¥3700.0 |
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Sal003
CAS No. : 1164470-53-4
MCE 国际站:Sal003
产品活性:Sal003 是高效、特异性的细胞渗透性 eIF2α 磷酸酶抑制剂。Sal003 是 salubrinal 的衍生物。
研究领域:Metabolic Enzyme/Protease | Apoptosis
作用靶点:Phosphatase | Apoptosis
In Vitro: Sal003 (20 μM; 1-12 hours) sharply increases eIF2α phosphorylation in mouse embryonic fibroblasts (MEFs).
?Eukaryotic translation initiation factor 2α (eIF2α) phosphorylation by Sal003 (10 μM; 1 hour) enhances subtilase cytotoxin (SubAB)-induced apoptotic signaling.
?Sal003 promotes eIF2α phosphorylation leads to impairment of synaptic plasticity and memory.
In Vivo: Sal003 (20Μm; intrahippocampal injection; 8 minutes) impairs contextual memory in vivo.
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