褪黑素 M5250-250MG

产品名称
Caution
Solutions are light sensitive and subject to oxidation.

包装
1, 5, 10 g in glass bottle

250 mg in glass bottle

Biochem/physiol Actions
Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

Features and Benefits
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

法律信息
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M5250.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
性质
Related Categories Alkaloid, Antitumor Agents, Application Index, Cell Signaling Enzymes, Chemopreventive Agents,
Cofactor, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Estrogen Response Modifiers, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Gene Regulation, L to O, Meatonin - Receptor Agonists, Melatonins, Membrane Protein Biology Tools, NOS Inhibitors, Neurobiology, Neuroscience, Nitric Oxide Metabolism, Nitric Oxide Synthase, Pharmacologicals, Phytochemicals by Chemical Classification, Tryptophan, 代谢组学, 代谢通路, 代谢通路图中的代谢产物和辅酶分子, 生化试剂, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 营养研究, 蛋白质及衍生物, 酶、抑制剂和底物
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assay ≥98% (TLC)
form powder
color white to off-white
mp 116.5-118 °C(lit.)
solubility ethanol: soluble50 mg/mL
storage temp. −20°C
Gene Information human ... MTNR1A(4543), MTNR1B(4544), NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)