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- 2025年10月28日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
蛋白表达区间:Arg29-Ala161
- 保质期：
See instructions
- 英文名：
标签:C-6His
- 库存：
表达系统:Human Cells
- 供应商：
上海经科化学科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ￥840.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2520.0 |
| 规格： | 500ug | 产品价格： | ￥12320.0 |
| 规格： | 1mg | 产品价格： | ￥17600.0 |
- Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
- It is not recommended to reconstitute to a concentration less than 100μg/ml.
- Dissolve the lyophilized protein in distilled water.
- Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- The product is shipped at ambient temperature.
- Upon receipt, store it immediately at the temperature listed below.
- Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
- Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
- Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
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文献和实验Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. Mouse and human IL-17F share 55% sequence identity.IL-17F has been shown to stimulate the production of several other cytokines, including IL-6, IL-8, and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. IL-17F is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. Defects in IL-17F are the cause of familial candidiasis type 6 (CANDF6).
【进展|热点】Immunity：IL-17A和IL-17F的生物效应不同
IL-17是Th17细胞最主要的效应因子，目前认为其家族成员包括IL-17A～F六种高度同源的细胞因子，其中Th17细胞分泌的IL-17主要是IL-17A和IL-17F，传统的观点认为IL-17A和IL-17F具有共同的受体，因此二者的生物效应相同，但是Immunity杂志在09年1月份刊登了一篇文章，作者通过观察IL-17A-/-、IL-17F-/-、IL-17A-/-IL-17F-/-的小鼠在黏膜感染以及过敏反映中的表现，指出Th17细胞的效应因子IL-17A和IL-17F在黏膜免疫和过敏
【进展|热点】Immunity:IL-17A和IL-17F的表达调控机制不同
IL-17A和IL-17F是Th17细胞的主要效应因子，在很长的一段时间内，人们一直认为二者结构高度同源，且受体相同，因此可能生物效应和表达调控机制也相同，在文献资料以及实验中并未对二者进行严格区分。 Immunity在2月份曾发表文章，指出IL-17A和IL-17F的生物学效应略有不同。 连接： http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSP-4VCPJNP-D&_user=2352871&_rdoc
Quantification of Mouse IL-6 and TNF- mRNA Using Xplore Assays
The production of cytokines can be controlled by the regulation of transcription, by the regulation of translation, and by post-translational mechanisms. Therefore, to understand better the control of cytokine production, it is important
技术资料
