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- 2025年10月30日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
蛋白表达区间:Met1-Asp552
- 保质期：
See instructions
- 英文名：
标签:C-6His
- 库存：
表达系统:E.coli
- 供应商：
上海经科化学科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ￥760.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2280.0 |
| 规格： | 500ug | 产品价格： | ￥12320.0 |
| 规格： | 1mg | 产品价格： | ￥17600.0 |
- Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
- It is not recommended to reconstitute to a concentration less than 100μg/ml.
- Dissolve the lyophilized protein in distilled water.
- Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- The product is shipped at ambient temperature.
- Upon receipt, store it immediately at the temperature listed below.
- Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
- Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
- Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
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文献和实验SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumor suppressor. It positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Mutations or deletions in SMAD4 have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
dingding2004 想找一个药物来阻断SMAD4 的作用。不知有没有做过的。 SMAD4 是在转录水平发挥作用的，如果有这种药物，加在要干预的细胞培养液中，可以发挥作用吗？ dingding2004 自己顶下啊 caoying207 唉，没想到2年以后，我也在找SMAD4阻断剂（抑制剂 ），前辈，你找到了吗？ skyzhuz 半
Molecular Detection of Smad2/Smad4 Alterations in Colorectal Tumors
The signaling pathways mediated by the transforming growth factor-β (TGF-β) family of factors are implicated in a wide array of biological processes including cell differentiation and proliferation, determination of cell fate during embryogenesis
Direct Sequencing for Juvenile Polyposis Gene SMAD4/DPC4 Mutations
Juvenile polyposis (JP) is a rare dominantly inherited tumor predisposition syndrome, the typical lesion being a benign hamartomatous intestinal polyp with dilated crypts. Solitary juvenile polyps are relatively common in childhood, and appear
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