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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
蛋白表达区间:Leu20-Gly237
- 保质期:
See instructions
- 英文名:
标签:C-6His
- 库存:
表达系统:Human Cells
- 供应商:
上海经科化学科技有限公司
- 规格:
10ug/50ug/500ug/1mg
| 规格: | 10ug | 产品价格: | ¥640.0 |
|---|---|---|---|
| 规格: | 50ug | 产品价格: | ¥1760.0 |
| 规格: | 500ug | 产品价格: | ¥12320.0 |
| 规格: | 1mg | 产品价格: | ¥17600.0 |
- Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
- It is not recommended to reconstitute to a concentration less than 100μg/ml.
- Dissolve the lyophilized protein in distilled water.
- Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- The product is shipped at ambient temperature.
- Upon receipt, store it immediately at the temperature listed below.
- Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
- Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
- Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
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文献和实验Coxsackievirus and Adenovirus Receptor (CAR) belongs to the CTX family of the Ig superfamily. CXADR is a type I transmembrane glycoprotein and expressed in pancreas, brain, heart, small intestine, testis, prostate. It is a receptor that mediates gene transfer and also act as an adhesion molecule within junctional complexes, notably between epithelial cells lining body cavities and within myocardial intercalated discs. CXADR contains an extracellular domain, a transmembrane helix and a C-terminal intracellular domain. The C-terminal interacts with few cytoplasmic junctional proteins, microtubules and the actin cytoskeleton.
细胞治疗技术正扮演着越来越重要的角色。其中,CAR-T 细胞治疗、间充质干细胞(MSC)治疗以及 T 细胞治疗是三种备受关注的细胞治疗方法。 这些治疗方法通过采集患者体内的特定细胞,经过体外激活、修饰、扩增等步骤,再将这些具有特定功能的细胞移植回患者体内,以达到治疗疾病的目的。为了更好地理解和应用这些治疗技术,下面我们将整合并详细叙述这三种细胞治疗的流程图内容,为研究人员和临床医生提供一个清晰的操作指南。 CAR-T 细胞治疗流程 间充质干细胞治疗流程 T 细胞治疗流程
「CAR-T 之父」Carl June 引领抗癌风向标!挑战
导读当前,嵌合抗原受体 (CAR)-T 细胞在白血病的治疗中已经取得了显著的进展,但是该疗法在大多数实体肿瘤中的疗效仍然受限。有学者认为,导致实体肿瘤疗效差的因素主要在于肿瘤微环境(TME)中免疫细胞的「捣乱」,这促使人们努力改善 CAR-T 细胞的内在功能,使其能够克服 TME 带来的抵抗,然而目前仍然没有突破性进展。损伤相关分子模式(Damage-associated molecular patterns, DAMPs)作为模式识别受体(Patter recognition
嵌合抗原受体T细胞免疫疗法,CAR-T疗法。目前已在血液系统恶性肿瘤的治疗中取得了重大成功,但也存在严重的可能致命的副作用,例如细胞因子风暴CRS和神经毒性。同时,CAR-T疗法目前对实体瘤治疗效果非常有限,且肿瘤相关抗原在很多重要且关键的正常组织都有表达,这也增加了“On target off tumor”的毒性。 针对CAR-T疗法的局限性,研究人员采取了许多策略试图克服这些局限性,例如增强T细胞的扩增和降低T细胞的耗竭、敲除抑制基因、提高T细胞识别抗原的灵敏度。本期陈老湿
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