Amphotericin B solubilized A

产品名称
Frequently Asked QuestionsLive Chat andFrequently Asked Questions are available for this Product.ComponentsThis product is a colloidal suspension of Amphotericin B, using deoxycholate as the solubilizing agent. The formulation is ~45% Amphotericin B and 35% sodium deoxycholate in sodium phosphate and sodium chloride.ApplicationAmphotericin B is a polyene antifungal antibiotic from Streptomyce sp. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium.Biochem/physiol ActionsAmphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out. The product is most effective against fungi and yeast.CautionAmphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.包装Solubilized Amphotericin B is packaged in a bottomless glass bottle, with the contents inside an inserted fused cone.Preparation NoteAmphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility. If reconstituted at 25mg/10mL of sterile water, there is no need to filter sterilize.Protocols & ApplicationsAntibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information
性质
Related CategoriesAntibiotic powders,Antibiotics,Antibiotics A to Z,Antibiotics A-F,Antifungal,
Chemical Structure Class,Interferes with Cell Membrane Permeability (Ionophores),Mechanism of Action,Polyenes,Spectrum of Activity,抗生素,生化试剂,细胞培养,试剂和添加剂更多...Quality Level PREMIUMsterility γ-irradiatedproduct line BioXtraform powdersolubility sterile water: soluble20 mg/mL (as a stock solution. Stock solutions should be stored at −20 °C. Stable at 37 °C for 3 days.)suitability suitable for cell cultureantibiotic activity spectrum molds