活性:
Measured by its binding ability in a functional ELISA. Immobilized Human IL17 /IL17A,Tag Free (Catalog # ILA-H5118) at 2 μg/mL (100 μL/well ) can bind Human IL-17 RA, Fc Tag (Catalog # ILA-H5257) with a linear ranger of 0.3 - 5 ng/mL.
产品背景:
Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
产品描述:
Human IL17A,Tag Free contains no "tag", and has a calculated MW of 15.1 kDa. The predicted N-terminus is Met. The reducing (R) protein migrates as 16 kDa in SDS-PAGE.