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- D1515
- 2025年11月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
2-8°C
- 保质期：
1年
- 英文名：
Doxorubicin hydrochloride
- 库存：
100⁺瓶
- 供应商：
上海睿安生物19121878899
- CAS号：
25316-40-9
- 规格：
10mg
Sigma货号D1515-10mg阿霉素盐酸盐Doxorubicin hydrochloride上海睿安生物19121878899
阿霉素 盐酸盐
98.0-102.0%(HPLC)
别名:阿霉素，DOX，多柔比星® 盐酸盐，羟基柔红霉素盐酸盐
说明
一般描述
盐酸阿霉素(DOX)是一种从波赛链霉菌青灰变种中分离出来的蒽环类抗生素。水溶性抗癌剂DOX是道诺霉素的羟基衍生物。
道诺霉素也导致活性氧(ROS)的生成，后者进一步破坏DNA、蛋白质和膜。 它具有细胞毒性、抗肿瘤、抗癌活性，可应用于癌症、代谢组学、细胞生物学和生物化学研究。
应用
盐酸阿霉素已用于：
细胞活力测定
MTT（3-(4,5-二甲基-2-噻唑基)-2,5-二苯基四唑的溴盐）测定
用作PLGA基聚合物微粒药物递送的药物
开发抗阿霉素的HepG2细胞 (HepG2-DR)和K562细胞(K562-DR)
生化/生理作用
MRP1的底物；用于测量药物外排泵的活性。盐酸阿霉素(DOX)通过插入碱基对之间并诱导链断裂，抑制拓扑异构酶II，进而抑制核酸和蛋白质的合成。[1]它还有助于形成自由基，从而破坏膜脂和DNA链。
天然荧光蒽环类抗生素，抗癌药物。阿霉素是一种MRP1的底物，首先从抗DOX的肺癌细胞系中克隆得到。荧光特性已被运用于测量药物外排泵的活性及解决多种多药耐药蛋白在细胞内定位的重要问题，以及亚细胞器（高尔基体和溶酶体）在药物隔离中及抗药性表型中的作用。
特点和优势
适合多种研究应用的高质量抗生素
非常适合细胞生物学、代谢组学、生化研究。
制备说明
密闭。干燥。置于通风良好处保存。上锁保存或放置在只有经过授权或有资质的人员才能进入的区域。
易溶于水和等渗氯化钠溶液，微溶于甲醇。几乎不溶于氯仿、(yǐ)醚和其他有机溶剂。
其他说明:保持容器密闭并置于干燥通风处。湿度敏感。光敏感。
常见问题
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
What is the excitation and emission wavelength for Product D1515, Doxorubicin hydrochloride?
Doxorubicin has excitation maximum at 470 nm and an emission maximum at 585 nm in ethanol.
What is the difference between Doxorubicin hydrochloride Products D1515 and D1317?
Product No. D1317, Doxorubicin hydrochloride solution has been discontinued and is no longer available. We now offer Product No. D1515 which is a powder.
How can I store a solution of Product D1515, Doxorubicin hydrochloride?
Aqueous solutions are unchanged after one month at 5 °C but unstable at higher temperatures or at either acid or alkaline pH. Several studies cite that stability is related to pH, exposure to light and the medium used for storage. Doxorubicin hydrochloride is subject to light degradation at <0.5 mg/mL, with considerable loss of bioactivity. If stored at 25 °C in the dark in 5% glucose, pH 4.7 (or 3.3% glucose + 0.3% sodium chloride, pH 4.4), solutions were stable (5% or less change) for at least 4 weeks.
What can be used to make a solution of Product D1515, Doxorubicin hydrochloride?
The solubility of doxorubicin is tested in water (50 mg/mL), yielding a clear orange to red solution.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
同行评审论文(部分:文献)
In vitro study of anticancer drug doxorubicin in PLGA-based microparticles
Lin R, et al.
Biomaterials, 26(21), 4476-4485 (2005)
Current Pharmaceutical Design (1999)
The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning
Xu X, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 70(1), 165-170 (2008)
Poly (ethylene glycol)-conjugated multi-walled carbon nanotubes as an efficient drug carrier for overcoming multidrug resistance
Cheng J, et al.
Toxicology and Applied Pharmacology, 250(2), 184-193 (2011)
Consumers Guide to Cancer Drugs (2004)
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文献和实验Sigma货号D1515-10mg阿霉素盐酸盐Doxorubicin hydrochloride上海睿安生物19121878899
阿霉素 盐酸盐
98.0-102.0%(HPLC)
别名:阿霉素，DOX，多柔比星® 盐酸盐，羟基柔红霉素盐酸盐
说明
一般描述
盐酸阿霉素(DOX)是一种从波赛链霉菌青灰变种中分离出来的蒽环类抗生素。水溶性抗癌剂DOX是道诺霉素的羟基衍生物。
道诺霉素也导致活性氧(ROS)的生成，后者进一步破坏DNA、蛋白质和膜。 它具有细胞毒性、抗肿瘤、抗癌活性，可应用于癌症、代谢组学、细胞生物学和生物化学研究。
应用
盐酸阿霉素已用于：
细胞活力测定
MTT（3-(4,5-二甲基-2-噻唑基)-2,5-二苯基四唑的溴盐）测定
用作PLGA基聚合物微粒药物递送的药物
开发抗阿霉素的HepG2细胞 (HepG2-DR)和K562细胞(K562-DR)
生化/生理作用
MRP1的底物；用于测量药物外排泵的活性。盐酸阿霉素(DOX)通过插入碱基对之间并诱导链断裂，抑制拓扑异构酶II，进而抑制核酸和蛋白质的合成。[1]它还有助于形成自由基，从而破坏膜脂和DNA链。
天然荧光蒽环类抗生素，抗癌药物。阿霉素是一种MRP1的底物，首先从抗DOX的肺癌细胞系中克隆得到。荧光特性已被运用于测量药物外排泵的活性及解决多种多药耐药蛋白在细胞内定位的重要问题，以及亚细胞器（高尔基体和溶酶体）在药物隔离中及抗药性表型中的作用。
特点和优势
适合多种研究应用的高质量抗生素
非常适合细胞生物学、代谢组学、生化研究。
制备说明
密闭。干燥。置于通风良好处保存。上锁保存或放置在只有经过授权或有资质的人员才能进入的区域。
易溶于水和等渗氯化钠溶液，微溶于甲醇。几乎不溶于氯仿、(yǐ)醚和其他有机溶剂。
其他说明:保持容器密闭并置于干燥通风处。湿度敏感。光敏感。
常见问题
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
What is the excitation and emission wavelength for Product D1515, Doxorubicin hydrochloride?
Doxorubicin has excitation maximum at 470 nm and an emission maximum at 585 nm in ethanol.
What is the difference between Doxorubicin hydrochloride Products D1515 and D1317?
Product No. D1317, Doxorubicin hydrochloride solution has been discontinued and is no longer available. We now offer Product No. D1515 which is a powder.
How can I store a solution of Product D1515, Doxorubicin hydrochloride?
Aqueous solutions are unchanged after one month at 5 °C but unstable at higher temperatures or at either acid or alkaline pH. Several studies cite that stability is related to pH, exposure to light and the medium used for storage. Doxorubicin hydrochloride is subject to light degradation at <0.5 mg/mL, with considerable loss of bioactivity. If stored at 25 °C in the dark in 5% glucose, pH 4.7 (or 3.3% glucose + 0.3% sodium chloride, pH 4.4), solutions were stable (5% or less change) for at least 4 weeks.
What can be used to make a solution of Product D1515, Doxorubicin hydrochloride?
The solubility of doxorubicin is tested in water (50 mg/mL), yielding a clear orange to red solution.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
同行评审论文(部分:文献)
In vitro study of anticancer drug doxorubicin in PLGA-based microparticles
Lin R, et al.
Biomaterials, 26(21), 4476-4485 (2005)
Current Pharmaceutical Design (1999)
The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning
Xu X, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 70(1), 165-170 (2008)
Poly (ethylene glycol)-conjugated multi-walled carbon nanotubes as an efficient drug carrier for overcoming multidrug resistance
Cheng J, et al.
Toxicology and Applied Pharmacology, 250(2), 184-193 (2011)
Consumers Guide to Cancer Drugs (2004)
Actidione（ Cycloheximide ） 放线菌酮 100mg 200 Sigma分装 B1022 ActinomycinD 放线菌素 D 1mg 250 Sigma分装 B1025 Alcian Blue 8 GX (阿尔新蓝,阿利
bitartrate）19mg相当于间羟胺10mg，肌内注射，间羟胺10mg/次；或10～20mg以葡萄糖液100亳升稀释后静脉滴注。极量静脉滴注100mg/次（每分钟0.2～0.4mg）。 盐酸去氧肾上腺素（phenylephrine hydrochloride）肌内注射，2～5mg/次；或10mg以葡萄糖液100ml稀释后静脉滴注。极量肌内注射10mg/次，静脉滴注每分钟0.18mg. 盐酸甲氧明（methoxamine hydrochloride） 肌内注射,10～20mg/次，或缓慢静脉
间羟胺（metaraminol bitartrate）19mg相当于间羟胺10mg，肌内注射，间羟胺10mg/次；或10～20mg以葡萄糖液100亳升稀释后静脉滴注。极量静脉滴注100mg/次（每分钟0.2～0.4mg）。 盐酸去氧肾上腺素（phenylephrine hydrochloride）肌内注射，2～5mg/次；或10mg以葡萄糖液100ml稀释后静脉滴注。极量肌内注射10mg/次，静脉滴注每分钟0.18mg. 盐酸甲氧明（methoxamine hydrochloride） 肌内注射,10～20
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