Sigma货号A9525现货Angiotensin II h

Sigma货号A9525现货Angiotensin II human人血管紧张素II上海睿安生物13611631389

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

应用

• 人血管紧张素II(angII)已被用于研究其对白介素1β介导的胰岛炎症和β细胞功能障碍的影响。
• 它还被用于确定angII是否激活心肌细胞中特定的钙调神经磷酸酶依赖性NFAT(活化T细胞的核因子)的同种型。
• 它已被用于研究全身性angII输注对体内血管小球通透性的作用。
• 它已被用于考察angII对血浆甘油三酯生产的影响及其与正常大鼠中胰岛素抵抗的关系。

生化/生理作用

血管紧张素II(angII)是一种八肽激素，可影响心脏、肾脏、脉管系统和大脑的活动。血液中的AngII是由血管紧张素原通过肾素和血管紧张素转换酶(ACE)产生的。它通过与细胞膜上的特定受体结合而起作用。AngII是肾素-血管紧张素系统的一个成分。它与血管收缩、血管平滑肌细胞生长的诱导、原癌基因表达的刺激、心肌肥大的调节、肾衰竭和纤维化有关。

特点和优势:

我们的人血管紧张素II(Ang II)的纯度经过验证，可确保您的实验成功(HPLC和肽含量)。肽序列是DRVYIHPF。

抗体吸附剂:Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH·2CH₃COOH·H₂O

分析说明:肽含量不低于75%

同行评审论文(部分文献)

Activation of PKG-CREB-KLF15 by melatonin attenuates Angiotensin II-induced vulnerability to atrial fibrillation via enhancing branched-chain amino acids catabolism.

Li-Ming Yu et al.

Free radical biology & medicine, 178, 202-214 (2021-12-06)

Mitochondrial reactive oxygen species (ROS) damage and atrial remodeling serve as the crucial substrates for the genesis of atrial fibrillation (AF). Branched-chain amino acids (BCAAs) catabolic defect plays critical roles in multiple cardiovascular diseases. However, the alteration of atrial BCAA

The renin-angiotensin-aldosterone system: a specific target for hypertension management.

M R Weir et al.

American journal of hypertension, 12(12 Pt 3), 205S-213S (2000-01-05)

Angiotensin II plays a central role in the regulation of systemic arterial pressure through its systemic synthesis via the renin-angiotensin-aldosterone cascade. It acts directly on vascular smooth muscle as a potent vasoconstrictor. In addition, it affects cardiac contractility and heart

Angiotensin II triggers expression of the adrenal gland zona glomerulosa-specific 3β-hydroxysteroid dehydrogenase isoenzyme through de novo protein synthesis of the orphan nuclear receptors NGFIB and NURR1.

Takumi Ota et al.

Molecular and cellular biology, 34(20), 3880-3894 (2014-08-06)

The 3β-hydroxysteroid dehydrogenase (3β-HSD) is an enzyme crucial for steroid synthesis. Two different 3β-HSD isoforms exist in humans. Classically, HSD3B2 was considered the principal isoform present in the adrenal. However, we recently showed that the alternative isoform, HSD3B1, is expressed

Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis.

Xiang He et al.

Theranostics, 9(19), 5558-5576 (2019-09-20)

Objective: Long noncoding RNAs (lncRNAs) may serve as specific targets for the treatment of abdominal aortic aneurysms (AAAs). LncRNA GAS5, functionally associated with smooth muscle cell (SMC) apoptosis and proliferation, is likely involved in AAA formation, but the exact role

Subcellular localization of angiotensin II immunoreactivity in the rat cerebellar cortex.

B Erdmann et al.

Hypertension (Dallas, Tex. : 1979), 28(5), 818-824 (1996-11-01)

We localized angiotensin II (Ang II) immunoreactivity in the rat cerebellar cortex with immunogold staining methods. Perfusion fixation with high amounts of glutaraldehyde and the use of cryoultramicrotomy caused remarkable changes in immunostaining versus formaldehyde/picric acid fixation. With the use

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