- ￥1506.26
- Sigma-Aldrich
- made in USA
- R9504-100g
- 2025年12月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Room temperature
- 保质期：
1年
- 英文名：
(−)-riboflavin
- 库存：
100⁺瓶
- 供应商：
上海睿安生物13611631389
- CAS号：
83-88-5
- 规格：
100g/瓶
Riboflavin核黄素Sigma货号R9504-25g现货13611631389上海睿安生物
Riboflavin核黄素Sigma货号R9504-100g现货13611631389上海睿安生物
(−)-核黄素
BioReagent,suitable for cell culture, suitable for insect cell culture,≥98%
别名:乳黄素，维生素B2，维生素G
说明
一般描述:核黄素支持细胞生长和新陈代谢，可协助研究人员进行研发。&在细胞培养中，它通常作为培养基配方中的关键组分。癌症研究人员研究其对氧化应激反应的影响。干细胞研究人员重视其在维持多功能性方面的作用。
核黄素是一种可溶于水的必需维生素。牛奶和鸡蛋是它的主要来源。核黄素通常与所有组织中的酶结合。核黄素在血浆中定位时，会与白蛋白和特异性免疫球蛋白结合。
应用:(-)-核黄素已用于实验小鼠腹腔注射给药，以研究其对大脑中动脉阻塞卒中的保护作用。它也可与克雷布斯液一起使用，以体外模拟类缺血状态。
生化/生理作用:核黄素是活性辅酶因子核黄素 5′ -单磷酸盐(也称为黄素单核苷酸或FMN)和黄素腺嘌呤二核苷酸(FAD)的前体。饮食中的核黄素缺乏会导致一种称为阿里波黄素沉积症的综合征，其症状包括唇炎、口角炎、舌炎、角膜炎和脂溢性皮炎。核黄素具有抗肿瘤发展和心血管疾病的保护作用。其缺乏常影响涉及氧化还原反应的代谢。核黄素对铁的吸收、胃肠道发育、神经发生、角膜血管化和角膜混浊都有重要作用。
同行评审论文(部分文献)
Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans.
Chia-An Yen et al.
eLife, 9 (2020-02-06)
Exposure to environmental stress is clinically established to influence male reproductive health, but the impact of normal cellular metabolism on sperm quality is less well-defined. Here we show that impaired mitochondrial proline catabolism, reduces energy-storing flavin adenine dinucleotide (FAD) levels
Riboflavin (vitamin B-2) and health
Powers Hilary J
American Journal of Clinical Nutrition, 77(6), 1352-1360 (2003)
Mitochondrial Abnormalities in Induced Pluripotent Stem Cells-Derived Motor Neurons from Patients with Riboflavin Transporter Deficiency.
Fiorella Colasuonno et al.
Antioxidants (Basel, Switzerland), 9(12) (2020-12-16)
Riboflavin transporter deficiency (RTD) is a childhood-onset neurodegenerative disorder characterized by sensorineural deafness and motor neuron degeneration. Since riboflavin plays key functions in biological oxidation-reduction reactions, energy metabolism pathways involving flavoproteins are affected in RTD. We recently generated induced pluripotent
Antioxidant enzyme levels in the erythrocytes of riboflavin-deficient and Trichinella spiralis-infected rats
Tumkiratiwong P, et al.
The Southeast Asian Journal of Tropical Medicine and Public Health, 34(3), 480-485 (2003)
Safety profile of high-fluence corneal collagen cross-linking for progressive keratoconus: preliminary results from a prospective cohort study.
Zisis Gatzioufas et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(12), 846-848 (2013-10-31)
To investigate the effect of high-fluence corneal collagen cross-linking (CXL) with riboflavin and ultraviolet-A in the management of progressive keratoconus. Preliminary results from a prospective cohort study. Seven eyes from 7 patients with progressive keratoconus subjected to CXL were included.
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文献和实验该产品被引用文献
Riboflavin核黄素Sigma货号R9504-25g现货13611631389上海睿安生物
Riboflavin核黄素Sigma货号R9504-100g现货13611631389上海睿安生物
(−)-核黄素
BioReagent,suitable for cell culture, suitable for insect cell culture,≥98%
别名:乳黄素，维生素B2，维生素G
说明
一般描述:核黄素支持细胞生长和新陈代谢，可协助研究人员进行研发。&在细胞培养中，它通常作为培养基配方中的关键组分。癌症研究人员研究其对氧化应激反应的影响。干细胞研究人员重视其在维持多功能性方面的作用。
核黄素是一种可溶于水的必需维生素。牛奶和鸡蛋是它的主要来源。核黄素通常与所有组织中的酶结合。核黄素在血浆中定位时，会与白蛋白和特异性免疫球蛋白结合。
应用:(-)-核黄素已用于实验小鼠腹腔注射给药，以研究其对大脑中动脉阻塞卒中的保护作用。它也可与克雷布斯液一起使用，以体外模拟类缺血状态。
生化/生理作用:核黄素是活性辅酶因子核黄素 5′ -单磷酸盐(也称为黄素单核苷酸或FMN)和黄素腺嘌呤二核苷酸(FAD)的前体。饮食中的核黄素缺乏会导致一种称为阿里波黄素沉积症的综合征，其症状包括唇炎、口角炎、舌炎、角膜炎和脂溢性皮炎。核黄素具有抗肿瘤发展和心血管疾病的保护作用。其缺乏常影响涉及氧化还原反应的代谢。核黄素对铁的吸收、胃肠道发育、神经发生、角膜血管化和角膜混浊都有重要作用。
同行评审论文(部分文献)
Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans.
Chia-An Yen et al.
eLife, 9 (2020-02-06)
Exposure to environmental stress is clinically established to influence male reproductive health, but the impact of normal cellular metabolism on sperm quality is less well-defined. Here we show that impaired mitochondrial proline catabolism, reduces energy-storing flavin adenine dinucleotide (FAD) levels
Riboflavin (vitamin B-2) and health
Powers Hilary J
American Journal of Clinical Nutrition, 77(6), 1352-1360 (2003)
Mitochondrial Abnormalities in Induced Pluripotent Stem Cells-Derived Motor Neurons from Patients with Riboflavin Transporter Deficiency.
Fiorella Colasuonno et al.
Antioxidants (Basel, Switzerland), 9(12) (2020-12-16)
Riboflavin transporter deficiency (RTD) is a childhood-onset neurodegenerative disorder characterized by sensorineural deafness and motor neuron degeneration. Since riboflavin plays key functions in biological oxidation-reduction reactions, energy metabolism pathways involving flavoproteins are affected in RTD. We recently generated induced pluripotent
Antioxidant enzyme levels in the erythrocytes of riboflavin-deficient and Trichinella spiralis-infected rats
Tumkiratiwong P, et al.
The Southeast Asian Journal of Tropical Medicine and Public Health, 34(3), 480-485 (2003)
Safety profile of high-fluence corneal collagen cross-linking for progressive keratoconus: preliminary results from a prospective cohort study.
Zisis Gatzioufas et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(12), 846-848 (2013-10-31)
To investigate the effect of high-fluence corneal collagen cross-linking (CXL) with riboflavin and ultraviolet-A in the management of progressive keratoconus. Preliminary results from a prospective cohort study. Seven eyes from 7 patients with progressive keratoconus subjected to CXL were included.
文献支持
Riboflavin核黄素Sigma货号R9504-100g现货13611631389上海睿安生物
￥1506.26
