- ¥1719
- selleckchem
- 进口
- S7353
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
低温
- 库存：
大量
- 供应商：
上海善然生物科技有限公司
- 规格：
5mg
EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes. Following DOT1L inhibition, EPZ004777 selectively inhibits proliferation of MLL-Rearranged cell lines and MLL-AF9-transformed murine hematopoietic cells. In addition, EPZ004777 also induces differentiation and apoptosis in MLL-rearranged cells. [1] EPZ004777 selectively inhibits proliferation of MLL–AF10 and CALM–AF10-transformed murine bone marrow cells. [2] DOT1L inhibition by EPZ004777 results in significantly decreased proliferation, decreased expression of MLL-AF6 target genes, and cell cycle arrest of MLL-AF6-transformed cells. [3]
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文献和实验相关实验
. Reid, G.E., Shang, H., Hogan, J.M., Lee, G.U., and McLuckey, S.A. 2002. Gas‐phase concentration, purification, and identification of whole proteins from complex mixtures. J. Am. Chem. Soc. 124:7353‐7362
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EPZ004777S7353
¥1719
