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INK 128 (MLN0128)S2811

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  • ¥1392
  • selleckchem
  • 进口
  • S2811
  • 2025年07月15日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      低温

    • 库存

      大量

    • 供应商

      上海善然生物科技有限公司

    • 规格

      5mg

    INK 128 exhibits an enzymatic inhibition activity against mTOR and more than 100-fold selectivity to PI3K kinases. [1] As TORC1/2 inhibitor, INK 128 inhibits both the phosphorylation of S6 and 4EBP1, the downstream substrates of TORC1, and selectively inhibits AKT phosphorylation at Ser473, the downstream substrate of TORC2. Furthermore, INK 128 also shows potent inhibition effects on cell lines resistant to rapamycin and pan-PI3K inhibitors. [2]

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    图标文献和实验
    相关实验
    • Phosphoamino acid analysis:Mark Kamps's method

      of PAA standards.15 min should be plenty. 13.Mark the plate with radioactive ink so that you can extrapolate where the origins were and can align the film unambigously with the plate and the PAA markers. 14.Expose the plate to flashed film with a screen

    • p16INK4A and Familial Melanoma

      by allowing uncontrolled cell proliferation. During the cell-division cycle, cells in transit pass from a stage termed G1 to the DNA synthesis (or S) phase. At G1 phase, cells continue to synthesize RNA and proteins and irrevocably commit to DNA synthesis

    • Kamps's Western Blotting Protocol

      to 30 min in 3% BSA in rinse buffer .This should be filtered prior to use.In Mark Kamps's original procedure,he used 5% BSA and 1% ovalbumin.3% BSA appears to work just as well.1% BSA may also work satisfactorily,but you may be pushing your luck

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