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- 详细信息
- 文献和实验
- 技术资料
- 抗体名:
5-Fluorocytosine (5-FC)
- 抗体英文名:
5-Fluorocytosine (5-FC)
- 克隆性:
多克隆
- 规格:
5g
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文献和实验Clinical Trials With GDEPT: Cytosine Deaminase and 5-Fluorocytosine
of converting the nontoxic prodrug 5-fluorocytosine (5-FC) to 5-fluorouracil (5-FU), which inhibits RNA and DNA synthesis during the S-phase of the cell cycle (1 ). This system has been used both in vitro and in preclinical studies showing antitumor activity
Intratumoral Gene Transfer of the Cytosine Deaminase Gene for the Treatment of Breast Cancer
the nontoxic prodrug 5-fluorocytosine (5-FC) to the toxic metabolite 5-fluorouracil (5-FU), which inhibits RNA and DNA synthesis during S-phase of the cell cycle (1 ,2 ). We have devised a transcriptionally targeted GPAT strategy in which expression of CD
药物靶向治疗(drugs targeting)机理可概括为病毒导向酶的药物前体治疗(virus directed enzyeme prodrug therapy,VDEPT),即用反转录病毒载体的外源基因转移到细胞内.该基因编码一种酶,此酶可将一种无害的药物前体转变为细胞毒素复合物。带有这一基因的病毒载体只在特殊组织或肿瘤细胞中而不在正常细胞中表达。例如,胞嘧啶脱氨酶(cytosine deaminase)可将无害的5-氟胞嘧啶(5-fluorocytosine,5-FC)转变为细胞
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