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- 保存条件：
-20℃
- 克隆性：
单克隆
- 抗体名：
Fumarate Hydratase (FH) (Internal Region) 抗体
- 规格：
0.1ml/0.2ml
yb190758 产品详细信息
Fumarate Hydratase (FH) (Internal Region) 抗体
anti-Fumarate Hydratase (FH) (Internal Region) antibody
抗原
Fumarate Hydratase (FH)
别名 FH, DDBDRAFT_0205237, DDBDRAFT_0231397, DDBDRAFT_0231400, DDB_0205237, DDB_0231397, DDB_0231400, HLRCC, LRCC, MCL, MCUL1, Fh1, im:7152785, ns:zf-e152, zf-e152, zgc:66253, zgc:77498, Fh, Fh-1
抗原表位
其他选择 Internal Region
适用
其他选择 人
宿主
其他选择 山羊
克隆类型
多克隆
标记
其他选择 非结合性
实验类型 Peptide ELISA
应用范围
其他选择 酶联免疫吸附测定（ELISA）, Western Blotting (WB)
Pubmed 找到1个引用
规格 100 μg
发货至 中国 (更改)
发货时间 24至29个工作日
产品细节 Fumarate Hydratase (FH) (Internal Region) 抗体
免疫原 Peptide with sequence C-HPNDHVNKSQSSND, from the internal region of the protein sequence according to NP_000134.2.
交叉反应 小鼠, 大鼠, 犬
纯化方法 Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
质量等级 Verified
目标详细情况 Fumarate Hydratase (FH) (Internal Region) 抗体
别名 Fumarase / FH
背景 Synonyms: fumarate hydratase, HLRCC, LRCC, MCL, MCUL1, fumarase, leiomyomatosis and renal cell cancer, multiple hereditary cutaneous leiomyomata
基因ID 2271, 14194, 24368
NCBI登录号 NP_000134
使用细节 Fumarate Hydratase (FH) (Internal Region) 抗体
应用备注 ELISA: antibody detection limit dilution 1:64000.
Western blot: Approx 48 kDa band observed in Human Kidney, Liver and Lung lysates (calculated MW of 54.6 kDa according to NP_000134.2). The observed molecular weight corresponds to earlier findings with antibodies from different sources. In transfected HEK293 transiently expressing Fumarase a band of approx. 55 kDa is observed. This band is not observed in the non-transfected HEK293.Recommended concentration: 0.01-0.03 µg/mL. Enzyme immunoassay: Sandwich-type ELISA with increasing amount of recombinant Fumarase captured by a rabbit antibody. Recommended reporter concentration: 1-2 µg/mL
限制 仅限研究用
贮存及处理 Fumarate Hydratase (FH) (Internal Region) 抗体
状态 Liquid
浓度 100µg/200µl
缓冲液 Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Minimize freezing and thawing.
储存条件 -20 °C
储存方法 Aliquot and store at -20 °C.
Fumarate Hydratase (FH) (Internal Region) 抗体
anti-Fumarate Hydratase (FH) (Internal Region) antibody
抗原
Fumarate Hydratase (FH)
别名 FH, DDBDRAFT_0205237, DDBDRAFT_0231397, DDBDRAFT_0231400, DDB_0205237, DDB_0231397, DDB_0231400, HLRCC, LRCC, MCL, MCUL1, Fh1, im:7152785, ns:zf-e152, zf-e152, zgc:66253, zgc:77498, Fh, Fh-1
抗原表位
其他选择 Internal Region
适用
其他选择 人
宿主
其他选择 山羊
克隆类型
多克隆
标记
其他选择 非结合性
实验类型 Peptide ELISA
应用范围
其他选择 酶联免疫吸附测定（ELISA）, Western Blotting (WB)
Pubmed 找到1个引用
规格 100 μg
发货至 中国 (更改)
发货时间 24至29个工作日
产品细节 Fumarate Hydratase (FH) (Internal Region) 抗体
免疫原 Peptide with sequence C-HPNDHVNKSQSSND, from the internal region of the protein sequence according to NP_000134.2.
交叉反应 小鼠, 大鼠, 犬
纯化方法 Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
质量等级 Verified
目标详细情况 Fumarate Hydratase (FH) (Internal Region) 抗体
别名 Fumarase / FH
背景 Synonyms: fumarate hydratase, HLRCC, LRCC, MCL, MCUL1, fumarase, leiomyomatosis and renal cell cancer, multiple hereditary cutaneous leiomyomata
基因ID 2271, 14194, 24368
NCBI登录号 NP_000134
使用细节 Fumarate Hydratase (FH) (Internal Region) 抗体
应用备注 ELISA: antibody detection limit dilution 1:64000.
Western blot: Approx 48 kDa band observed in Human Kidney, Liver and Lung lysates (calculated MW of 54.6 kDa according to NP_000134.2). The observed molecular weight corresponds to earlier findings with antibodies from different sources. In transfected HEK293 transiently expressing Fumarase a band of approx. 55 kDa is observed. This band is not observed in the non-transfected HEK293.Recommended concentration: 0.01-0.03 µg/mL. Enzyme immunoassay: Sandwich-type ELISA with increasing amount of recombinant Fumarase captured by a rabbit antibody. Recommended reporter concentration: 1-2 µg/mL
限制 仅限研究用
贮存及处理 Fumarate Hydratase (FH) (Internal Region) 抗体
状态 Liquid
浓度 100µg/200µl
缓冲液 Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Minimize freezing and thawing.
储存条件 -20 °C
储存方法 Aliquot and store at -20 °C.
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文献和实验相关实验
Mol Cell：南京医科大学钱旭团队揭示延胡索酸促进肿瘤恶化新机制
的 Fumarate 通过半胱氨酸琥珀酸化修饰 PTEN，抑制 PTEN 生物学活性，进一步促进肿瘤恶性进程。 延胡索酸（Fumarate）是三羧酸循环的重要中间代谢产物，能够通过延胡索酸水合酶（Fumarate Hydratase, FH）生成苹果酸，有研究表明 FH 在多种肿瘤中常发生突变，而 FH 的失活突变直接导致肿瘤细胞内 Fumarate 累积，促进肿瘤的发生发展。已有报道表明 Fumarate 做为 α-酮戊二酸（α-KG）的类似物，能够介导表观遗传重编程，其通过竞争性抑制 α-KG 依赖的组蛋白
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Fumarate Hydratase (FH) (Internal Region) 抗体
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