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- 保存条件：
-20℃
- 克隆性：
单克隆
- 抗体名：
BCL2 Binding Component 3 (BBC3) (N-Term) 抗体
- 规格：
0.1ml/0.2ml
BCL2 Binding Component 3 (BBC3)
别名 BBC3, Puma, JFY-1, JFY1, PUMA, PUMA/JFY1
抗原表位
其他选择 N-Term
适用
其他选择 人
宿主
其他选择 兔
克隆类型
多克隆
标记
其他选择 非结合性
应用范围
其他选择 Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), 免疫组织化学石蜡技术（IHC-P）
Pubmed 找到1个引用
规格 0.1 mg
发货至 中国 (更改)
发货时间 29至35个工作日
产品编号 yb264889
产品细节 BCL2 Binding Component 3 (BBC3) (N-Term) 抗体
免疫原 N-terminal amino acids of Human PUMA
亚型 IgG
特异性 This antibody detects a 23 kDa protein corresponding to the molecular mass of PUMA on SDS PAGE immunoblots.
纯化方法 Affinity Chromatography
目标详细情况 BCL2 Binding Component 3 (BBC3) (N-Term) 抗体
别名 PUMA
背景 Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 up-regulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-α and PUMA-β (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.Synonyms: BBC3, Bcl-2-binding component 3, JFY-1, p53 up-regulated modulator of apoptosis
基因ID 27113
NCBI登录号 NP_001120712
UniProt Q9BXH1
研究领域 Cancer, Apoptosis/Necrosis, Metabolism
使用细节 BCL2 Binding Component 3 (BBC3) (N-Term) 抗体
应用备注 Western blot: 1: 500. Immunohistochemistry: 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
贮存及处理 BCL2 Binding Component 3 (BBC3) (N-Term) 抗体
状态 Liquid
浓度 1.0 mg/mL
缓冲液 PBS, 0.02 % Sodium Azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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文献和实验-1 and -3), which are associated with the IL-2R beta and gamma subunits, respectively, are also activated after binding of IL-2 to its receptor. Phosphorylation of the cytoplasmic domains of the betaƒn- and gammaƒn-subunits of the IL-2R provides docking sites for the JAK
, 473-476, 2001. 5. Hanlon S.E., Lieb J.D.. Progress and challenges in profiling the dynamics of chromatin and transcription factor binding with DNA microarrays. Curr. Opin. Genet. Dev. 14, 697-705, 2004. 6. Banerjee N., Zhang M.Q.. Identifying
网络 免疫球蛋白分子的结构与功能 一、免疫球蛋白分子的基本结构 Porter等对血清IgG抗体的研究证明，Ig分子的基本结构是由四肽链组成的。即由二条相同的分子量较小的肽链称为轻链和二条相同的分子量较大的肽链称为重链组成的。轻链与重链是由二硫键连接形成一个四肽链分子称为Ig分子的单体，是构成免疫球蛋白分子的基本结构。Ig单体中四条肽链两端游离的氨基或羧基的方向是一致的，分别命名
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