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- 2025年07月12日
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- 技术资料
- 保存条件：
-20℃
- 克隆性：
单克隆
- 抗体名：
Mdm4-binding Protein (MDM4) (N-Term) 抗体
- 规格：
0.1ml/0.2ml
Mdm4-binding Protein (MDM4)
别名 mdmx, HDMX, MDMX, MRP1, wu:fa09h09, wu:fi33d10, 4933417N07Rik, AA414968, AL023055, AU018793, AU021806, C85810, Mdmx
抗原表位
其他选择 N-Term
适用
其他选择 犬, 牛, 人
宿主
其他选择 兔
克隆类型
多克隆
标记
其他选择 非结合性
应用范围
其他选择 Western Blotting (WB)
Pubmed 找到1个引用
规格 100 μg
发货至 中国 (更改)
发货时间 9至12个工作日
产品编号 yb184183
产品细节 Mdm4-binding Protein (MDM4) (N-Term) 抗体
免疫原 Synthetic peptide directed towards the N terminal of human MDM4
序列 MLRKNLVTLA TATTDAAQTL ALAQDHSMDI PSQDQLKQSA EESSTSRKRT
预测反应 Human : 100 %, Dog : 90 %, Horse : 90 %, Pig : 80 %, Bovine : 80 %, Rabbit : 80 %
产品特性 This is a rabbit polyclonal antibody against MDM4. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Protein A purified
目标详细情况 Mdm4-binding Protein (MDM4) (N-Term) 抗体
别名 MDM4
背景 MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions.The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2.
分子量 55 kDa
基因ID 4194
NCBI登录号 NP_002384, NM_002393
UniProt O15151
使用细节Mdm4-binding Protein (MDM4) (N-Term) 抗体
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明
Antigen size: 490 AA
限制 仅限研究用
贮存及处理 Mdm4-binding Protein (MDM4) (N-Term) 抗体
状态 Lyophilized
溶解方式 Add 100 µL of distilled water.
浓度 1 mg/mL
缓冲液 PBS buffer with 2 % sucrose
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For longer periods of storage, store at -20 °C
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文献和实验Knowledge-Based Virtual Screening: Application to the MDM4/p53 ProteinProtein Interaction
or conserved molecular recognition. Herein, we demonstrate the potential of knowledge-based virtual screening by applying it to the MDM4-p53 protein–protein interaction where the MDM2-p53 protein–protein interaction constitutes the parent reference
ANTIBODY BINDING TO PROTEIN A AND PROTEIN G
with non-immune reactivity for immunoglobulin G. J. Immunol. 111:1401-1406. Richman, D. D., Cleveland, P. H., Oxman, M. N., and Johnson, K. M. 1982. The binding of staphylococcl protein A by the sera of different animal species. J. Immunol. 128
DNase I Footprint Analysis of Protein‐DNA Binding
I (DNase I) protection mapping, or footprinting, is a valuable technique for locating the specific binding sites of proteins on DNA. The basis of this assay is that bound protein protects the phosphodiester backbone of DNA from DNase I?catalyzed hydrolysis
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