MLL Antibody

MLL Antibody

Cat#：PL0402411

Isotype:Rabbit Polyclonal IgG

Immunogen：peptide corresponding to a sequence at the N-terminus of human KMT2A.

Purification: Immunogen affinity purified

Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)

Background：

MLL(Myeloid/lymphoid or mixed Lineage Leukemia gene),also called MLL1, ALL1 or CXX7, is a frequent target for recurrent translocations in acute leukemias that may be characterized as acute myeloid leukemia(AML), acute lymphoblastic leukemia(ALL), or mixed lineage(biphenotypic) leukemia(MLL). The MLL gene encodes a DNA-binding protein that methylates histone H3 lys4(H3K4) and positively regulates expression of target genes, including multiple HOX genes. The MLL gene is mapped on 11q23.3. A leukemogenicMLL fusion protein that activates HOX expression had no effect on histone methylation, suggesting a distinct mechanism for gene regulation by MLLand MLL fusion proteins. The MLL gene encodes a large nuclear protein that is required for the maintenance of HOX gene expression. MLL is cleaved at 2 conserved sites to generate an N-terminal 320-kD fragment(N320) and a C-terminal 180-kD fragment(C180), which heterodimerize to stabilize the complex and confer its subnuclear destination.

Specificity Reaction：Hu, Mo

Application Notes:WB: 1:100-500

Storage ：

Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.

This product for research use only, not for use in humans, therapeutic or diagnostic procedures.

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